Primate-specific response of astrocytes to stroke limits peripheral macrophage infiltration
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Summary
Single nuclei transcriptomics is utilized to characterize astrocytes after ischemic stroke in nonhuman primate (NHP) marmoset monkey primary visual cortex and determined that NogoA mediated an anti-inflammatory response which limits deeper infiltration of peripheral macrophages from the lesion during the subacute post-stroke period.
- Type
- preprint
- Published
- 2020-05-10
- Cited by
- 5
- References
- 98
- Access
- Open access
- OpenAlex
- https://openalex.org/W3020977482
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:218631661
Keywords
Astrocyte, Microglia, Neuroscience, Stroke (engine), Marmoset
References
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- Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
- CD44: molecular interactions, signaling and functions in the nervous system
- A Reproducible and Translatable Model of Focal Ischemia in the Visual Cortex of Infant and Adult Marmoset Monkeys
- Estrogen Mediates Neuroprotection and Anti-Inflammatory Effects during EAE through ERα Signaling on Astrocytes But Not through ERβ Signaling on Astrocytes or Neurons
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- Retinal afferents synapse with relay cells targeting the middle temporal area in the pulvinar and lateral geniculate nuclei
- Heterogeneity of reactive astrocytes
- Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages
Cited by
- Improved post-stroke spontaneous recovery by astrocytic extracellular vesicles
- Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?
- Modelling behaviors relevant to brain disorders in the nonhuman primate: are we there yet?
- Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke
- Proteomic profiling of interferon-responsive reactive astrocytes in rodent and human
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