Gene editing and CRISPR in the clinic: current and future perspectives
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Summary
The current status and scientific basis of clinical trials featuring ZFNs, TALENs, andCRISPR-based genome editing, the known limitations of CRISPR use in humans, and the rapidly developing CRISpr engineering space that should lay the groundwork for further translation to clinical application are examined.
- Type
- review
- Published
- 2020-03-24
- Cited by
- 142
- References
- 315
- Access
- Open access
- OpenAlex
- https://openalex.org/W3012901598
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:214629311
Keywords
CRISPR, Genome editing, Current (fluid), Computational biology, Gene
References
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- Targeted DNA Demethylation and Endogenous Gene Activation Using Programmable TALE-TET1 Fusions
- Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
Cited by
- CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions
- CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury
- Insight into Salivary Gland Aquaporins
- DNA Damage: From Threat to Treatment
- Advances in engineering CRISPR-Cas9 as a molecular Swiss Army knife
- Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics
- Novel Antiviral Strategies in the Treatment of COVID-19: A Review
- Beyond CAR T cells: Engineered Vγ9Vδ2 T cells to fight solid tumors
- The PTEN Conundrum: How to Target PTEN-Deficient Prostate Cancer
- β-Hemoglobinopathies: The Test Bench for Genome Editing-Based Therapeutic Strategies
- Emerging Role and Therapeutic Potential of lncRNAs in Colorectal Cancer
- CRISPR-Cas “Non-Target” Sites Inhibit On-Target Cutting Rates
- Gene Therapy for Progressive Familial Intrahepatic Cholestasis: Current Progress and Future Prospects
- Therapeutic gene editing strategies using CRISPR-Cas9 for the β-hemoglobinopathies
- CRISPR-Cas Systems: Prospects for Use in Medicine
- Designer nucleases to treat malignant cancers driven by viral oncogenes
- Understanding and treating paediatric hearing impairment
- CRISPR-based strategies in infectious disease diagnosis and therapy
- Spontaneous Lung Fibrosis Resolution Reveals Novel Anti-Fibrotic Regulators.
- CRISPR based genome editing and removal of human viruses.
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