Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis
Explore this paper's citation graph
Summary
It is found that the ellagitannins from pomegranate leaves suppressed mPGES-1 expression without affecting COX-2, and showed anti-inflammatory and anti-carcinogenic effects.
- Type
- article
- Published
- 2019-12-22
- Cited by
- 26
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W2996121071
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:209447164
Keywords
Nitric oxide synthase, Chemistry, Apoptosis, Prostaglandin, Prostaglandin E
References
- Cyclooxygenase-2 Gene Transcription in a Macrophage Model of Inflammation1
- TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future.
- Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells
- Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects.
- Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function.
- Constituents of Geranium thunbergii SIEB. et ZUCC. XV. Modified Dehydroellagitannins, Geraniinic Acids B and C, and Phyllanthusiin F
- Coxibs and cardiovascular disease.
- 13C Nuclear Magnetic Resonance Spectra of Corilagin and Geraniin
- Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1
- Metabolites of the Ellagitannin Geraniin and Their Antioxidant Activities
- Hydrolysable tannins having enantiomeric dehydrohexahydroxydiphenoyl group: Revised structure of terchebin and structure of granatin B
- Arachidonic Acid Cascade and Signal Transduction
- Transcriptional Regulation of the Membrane-associated Prostaglandin E2 Synthase Gene
- Characterization of microsomal prostaglandin E synthase 1 inhibitors.
- Tannins and related compounds. C. Reaction of dehydrohexahydroxydiphenic acid esters with bases, and its application to the structure determination of pomegranate tannins, granatins A and B.
- COX-2 inhibitors and cardiovascular risk.
- Punicafolin, an ellagitannin from the leaves of Punica granatum
- Curcumin Suppresses Interleukin 1β-Mediated Microsomal Prostaglandin E Synthase 1 by Altering Early Growth Response Gene 1 and Other Signaling Pathways
- Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities.
- A Splice Site Mutation in Laminin-α2 Results in a Severe Muscular Dystrophy and Growth Abnormalities in Zebrafish
Cited by
- Rehabilitation treatment of enteral nutrition whey protein in lung cancer patients in southern China
- The Role of Tumor Inflammatory Microenvironment in Lung Cancer
- An overview on the role of plant-derived tannins for the treatment of lung cancer.
- Autophagy in Gastric Mucosa: The Dual Role and Potential Therapeutic Target
- Variation of the Polyphenolic Composition and Antioxidant Capacity of Freshly Prepared Pomegranate Leaf Infusions over One-Day Storage
- The Kinetics of Two-Step Ellagitannin Extraction from the By-products of Selected Processed Fruits of the family Rosaceae
- New Properties and Mitochondrial Targets of Polyphenol Agrimoniin as a Natural Anticancer and Preventive Agent
- Granatin B and punicalagin from Chinese herbal medicine pomegranate peels elicit reactive oxygen species-mediated apoptosis and cell cycle arrest in colorectal cancer cells.
- Geraniin inhibits whole blood IFN-γ and IL-6 and promotes IL-1β and IL-8, and stimulates calcium-dependent and sucrose-sensitive erythrocyte death.
- Pharmacotherapeutic potential of pomegranate in age-related neurological disorders
- An insight into the neuroprotective effects and molecular targets of pomegranate (Punica granatum ) against Alzheimer’s disease
- Punica granatum leaves as a source of active compounds: A review of biological activities, bioactive compounds, food, and technological application
- Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors
- The Therapeutic Alliance between Pomegranate and Health Emphasizing on Anticancer Properties
- Study on the antineoplastic and toxicological effects of pomegranate (Punica granatum L.) leaf infusion using the K14-HPV16 transgenic mouse model.
- Pomegranate: A review of the heavenly healer’s past, present, and future
- Bioactive compounds from pomegranate peels - Biological properties, structure–function relationships, health benefits and food applications – A comprehensive review
- Unlocking the therapeutic treasure of pomegranate leaf: A comprehensive review on phytochemical compounds, health benefits, and future prospects
- Phytochemical composition of wild pomegranate juices and their cytotoxicity
- Cell Type-Specific Anti- and Pro-Oxidative Effects of Punica granatum L. Ellagitannins
Related papers
- Terminal Deoxynucleotidyl Transferase (TdT)-Mediated dUTP Nick-End Labeling (TUNEL) for Detection of Apoptotic Cells in Drosophila.
- Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: analysis by terminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling(ヒト大腸癌の原発巣と転移巣におけるアポトーシスTUNEL法による解析)
- Detection of apoptosis by TUNEL assay.
- Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice.
- Kinetics of prostaglandin E metabolism in isolated hepatocytes.
- Effects of Changes in Sodium Balance on Prostaglandin Synthesis and Prostaglandin E2 9-Ketoreductase Activity in the Rat Kidney
- Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2).
- Mechanism of increased renal prostaglandin E2 in uranyl nitrate-induced acute renal failure.