Phenotypes of osteoarthritis - current state and future implications
Explore this paper's citation graph
Summary
The latest advances in OA phenotyping are discussed including how new modern statistical strategies based on machine learning and big data can help advance this field of research.
- Type
- review
- Published
- 2019-09-01
- Cited by
- 156
- References
- 90
- Access
- Open access
- OpenAlex
- https://openalex.org/W2988049777
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:204757322
Keywords
Medicine, Osteoarthritis, Big data, Data science, Phenotype
References
- Senescent cells and osteoarthritis: a painful connection
- Precision medicine--personalized, problematic, and promising.
- Inflammatory Biomarkers and Physical Function in Older, Obese Adults with Knee Pain and Self‐Reported Osteoarthritis After Intensive Weight‐Loss Therapy
- Overview of object oriented data analysis
- ALPHA-CTX is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis
- Soluble Macrophage Biomarkers Indicate Inflammatory Phenotypes in Patients With Knee Osteoarthritis
- Osteoarthritis: a disease of the joint as an organ.
- Increased IL-1 beta gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis
- Diseased Region Detection of Longitudinal Knee Magnetic Resonance Imaging Data
- Direction-Projection-Permutation for High-Dimensional Hypothesis Tests
- Statistical Significance of Clustering for High-Dimension, Low–Sample Size Data
- Identifying specific profiles in patients with different degrees of painful knee osteoarthritis based on serological biochemical and mechanistic pain biomarkers: a diagnostic approach based on cluster analysis
- Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis
- Distance-Weighted Discrimination
- Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease.
- Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
- Sex hormones and structural changes in osteoarthritis: a systematic review.
- The individual and socioeconomic impact of osteoarthritis
- Serious joint-related adverse events in randomized controlled trials of anti-nerve growth factor monoclonal antibodies.
- Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment - a systematic approach.
Cited by
- A machine learning approach to knee osteoarthritis phenotyping: Data from the FNIH Biomarkers Consortium
- Identifying Pain Susceptibility Phenotypes in Knee Osteoarthritis
- Disease modification in osteoarthritis: are we there yet?
- Distinct tribological endotypes of pathological human synovial fluid reveal characteristic biomarkers and variation in efficacy of viscosupplementation at reducing local strains in articular cartilage
- Recent advances in the treatment of osteoarthritis
- Identification of TGFβ signatures in six murine models mimicking different osteoarthritis clinical phenotypes.
- Knee osteoarthritis: key treatments and implications for physical therapy.
- Emerging pharmaceutical therapies for osteoarthritis
- Reorganization of functional brain network architecture in chronic osteoarthritis pain
- Osteoarthritis Year in Review 2020: Epidemiology & Therapy.
- How feasible is the stratification of osteoarthritis phenotypes by means of artificial intelligence?
- Application of Heterogeneity of Treatment Effect Methods: Exploratory Analyses of a Trial of Exercise-Based Interventions for Knee OA
- The relationship between abnormal Core binding factor-β expression in human cartilage and osteoarthritis
- Diagnosis and treatment of hip and knee osteoarthritis: A review
- Resistin induces chemokine and matrix metalloproteinase production via CAP1 receptor and activation of p38-MAPK and NF-κB signalling pathways in human chondrocytes.
- Activités physiques, sédentarité, comorbidités et arthrose
- Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus
- New Trends in Pharmacological Treatments for Osteoarthritis
- Existing Practices in Managing Osteoarthritis
- Dietary Interventions with Polyphenols in Osteoarthritis: A Systematic Review Directed from the Preclinical Data to Randomized Clinical Studies
Related papers
- A Study on the Application of Big Data to the Korean College Education System
- Application of Big Data in the Role of Medical Field
- Big Data Analytics in MOOCs
- Research on Kindergarten Science Field Teaching Based on Big Data Analysis
- Challenges and Issues in Data Analytics
- Big Data Analytics: A Field of Opportunities for Information Systems and Technology Researchers
- Big Data and Machine Learning Framework in Healthcare
- Conceptual notion for opinion mining from upcoming big data