Dietary Interventions with Polyphenols in Osteoarthritis: A Systematic Review Directed from the Preclinical Data to Randomized Clinical Studies
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Summary
Data indicate that combined polyphenols may be promising for the treatment of osteoarthritis in the future, but more clinical trials with novel approaches in the identification of the in-between relationship of such constituents are needed.
- Type
- review
- Published
- 2021-04-23
- Cited by
- 27
- References
- 74
- Access
- Open access
- OpenAlex
- https://openalex.org/W3159298588
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:233461801
Keywords
Osteoarthritis, Nutraceutical, Medicine, Polyphenol, Clinical trial
References
- Distribution of Constituents and Metabolites of Maritime Pine Bark Extract (Pycnogenol®) into Serum, Blood Cells, and Synovial Fluid of Patients with Severe Osteoarthritis: A Randomized Controlled Trial
- High-Rosmarinic Acid Spearmint Tea in the Management of Knee Osteoarthritis Symptoms
- The critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review
- Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)
- Pycnogenol supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis
- A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology.
- Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee.
- Flavocoxid Inhibits Phospholipase A2, Peroxidase Moieties of the Cyclooxygenases (COX), and 5-Lipoxygenase, Modifies COX-2 Gene Expression, and Acts as an Antioxidant
- Dietary polyphenols and mechanisms of osteoarthritis.
- Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis
- The role of reactive oxygen species in homeostasis and degradation of cartilage.
- Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study.
- Redox Regulation of Cell Survival
- Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee
- Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.
- Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®
- Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis
- Call for Standardized Definitions of Osteoarthritis and Risk Stratification for Clinical Trials and Clinical Use
- The search for cytotoxic synergy between anticancer agents: a case of Dorothy and the ruby slippers?
- Flavocoxid, a dual inhibitor of cyclooxygenase and 5‐lipoxygenase, blunts pro‐inflammatory phenotype activation in endotoxin‐stimulated macrophages
Cited by
- Phytochemical Analysis and Anti-Inflammatory Activity of Different Ethanolic Phyto-Extracts of Artemisia annua L.
- Phytochemicals Mediate Autophagy Against Osteoarthritis by Maintaining Cartilage Homeostasis
- The Role of Nutraceuticals in Osteoarthritis Prevention and Treatment: Focus on n-3 PUFAs
- Polygenetic Variants Related to Osteoarthritis Risk and Their Interactions with Energy, Protein, Fat, and Alcohol Intake in Adults in a Large Cohort
- Inhibitory activities of grape bioactive compounds against enzymes linked with human diseases
- Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms
- A Literature Review on Plant-Based Foods and Dietary Quality in Knee Osteoarthritis
- Higher dietary phytochemical index is associated with lower odds of knee osteoarthritis
- Valorization of Grape Pomace and Berries as a New and Sustainable Dietary Supplement: Development, Characterization, and Antioxidant Activity Testing
- Clinical Trials of Vitamin Supplements: Are They Meeting the European Medicines Agency Prompt Dissemination Regulation?
- Potential role of nutraceuticals via targeting a Wnt/β-catenin and NF-κB pathway in treatment of osteoarthritis.
- The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway
- A standardized nutraceutical supplement contributes to pain relief, improves quality of life and regulates inflammation in knee osteoarthritis patients; A randomized clinical trial
- Effects of Functional and Nutraceutical Foods in the Context of the Mediterranean Diet in Patients Diagnosed with Breast Cancer
- Diet modification reduces pain and improves function in adults with osteoarthritis: a systematic review.
- Anti-inflammatory activity of the combination Ardisia humilis Vahl. and Curcuma xanthorrhiza Roxb. extract on an osteoarthritis rat model
- Triangular Relation of Food Processing, Nutrition, and Osteoarthritis: A Solution for the Management and Prevention of Osteoarthritis?
- Nanozyme‐Engineered Hyaluronic Acid Adhesives Loading Platelet‐Rich Plasma for Multilayered Osteoarthritis Treatment with Pain‐Relief Effect
- Cathepsin K Inhibitors as Potential Drugs for the Treatment of Osteoarthritis
- Neuro-Nutritional Approach to Neuropathic Pain Management: A Critical Review
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