SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan

Keywords

SIRT6, AMPK, Endocrinology, Inflammation, Phenotype

References

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• A transgenic mouse marking live replicating cells reveals in vivo transcriptional program of proliferation.Agnes Klochendler, Noa Weinberg-Corem, Maya Moran — 2012
• AMPK at the Nexus of Energetics and AgingKristopher Burkewitz, Yue Zhang, William B. Mair — 2014
• Structure and Biochemical Functions of SIRT6*Patricia W. Pan, Jessica L. Feldman, Mark Devries — 2011
• Reduced Expression of MYC Increases Longevity and Enhances HealthspanJeffrey W. Hofmann, Xiaoai Zhao, Marco De Cecco — 2015
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Cited by

• The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasomeJavier Traba, Michael N. Sack — 2016
• Key proteins and pathways that regulate lifespanHaihui Pan, Toren Finkel — 2017
• The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophySadhana Samant, Abhinav Kanwal, Vinodkumar B. Pillai — 2017
• Sirtuin 6 Builds a Wall Against Inflammation, Trumping DiabetesWilliam Giblin, David B. Lombard — 2017
• Breaking the Ceiling of Human Maximal Life spanMoshe Shay Ben-Haim, Yariv Kanfi, Sarah J. Mitchell — 2018
• Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility.Carla Tatone, Giovanna Di Emidio, Arcangelo Barbonetti — 2018
• Natural polyphenols as sirtuin 6 modulatorsMinna Rahnasto‐Rilla, Jonna Tyni, Marjo Huovinen — 2018
• Neuron‐specific overexpression of core clock genes improves stress‐resistance and extends lifespan of Drosophila melanogasterIlya Solovev, Eugenia Dobrovolskaya, Mikhail Shaposhnikov — 2019
• NAD+ Metabolism in Aging and CancerTyler G. Demarest, Mansi Babbar, Mustafa Nazir Okur — 2019
• The Genetics of Aging: A Vertebrate PerspectiveParam Priya Singh, Brittany A. Demmitt, Ravi D. Nath — 2019
• The Role of Vascular Aging in Atherosclerotic Plaque Development and Vulnerability.Luca Liberale, Giovanni G. Camici — 2019
• Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study.Luca Liberale, Daniel S. Gaul, Alexander Akhmedov — 2020
• DNA Break-Induced Epigenetic Drift as a Cause of Mammalian AgingMotoshi Hayano, Jae-Hyun Yang, Michael S. Bonkowski — 2019
• Proteomics of long-lived mammalsGregory Tombline, Jonathan Gigas, Nicholas Macoretta — 2019
• SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARαShoshana Naiman, Frank K. Huynh, Reuven Gil — 2019
• Age-related epigenetic drift deregulates SIRT6 expression and affects its downstream genes in human peripheral blood mononuclear cellsMagdalena Owczarz, Jacek Połosak, Anna Domaszewska-Szostek — 2020
• Genetics of extreme human longevity to guide drug discovery for healthy ageingZhengdong D. Zhang, Sofiya Milman, Jhih‐Rong Lin — 2020
• Sirtuins as Possible Predictors of Aging and Alzheimer’s Disease Development: Verification in the Hippocampus and SalivaA. E. Pukhalskaia, Anastasiia Dyatlova, N. S. Linkova — 2020
• Nitro-fatty acids as activators of hSIRT6 deacetylase activityMara Carreño, Mariana Bresque, Matías Machado — 2020
• Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative DiseaseSwapnil Raj, Liston Augustine Dsouza, Shailendra Pratap Singh — 2020

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