Pulmonary toxicity in rats following inhalation exposure to poorly soluble particles: The issue of impaired clearance and the relevance for human health hazard and risk assessment.
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Summary
Unless available data clearly point out otherwise, rat pulmonary toxicity including lung inflammation and tumour formation, needs to be considered relevant for human hazard and risk assessment.
- Type
- review
- Published
- 2019-12-01
- Cited by
- 30
- References
- 78
- Access
- Open access
- OpenAlex
- https://openalex.org/W2979433383
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:204332368
Keywords
Medicine, Toxicity, Inhalation, Risk assessment, Inhalation exposure
References
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- Investigation of a potential cotumorigenic effect of the dioxides of nitrogen and sulfur, and of diesel-engine exhaust, on the respiratory tract of Syrian golden hamsters.
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- A mechanistic review of silica-induced inhalation toxicity
- Emphysema alters the deposition pattern of inhaled particles in hamsters.
- Species differences in NO formation by rat and hamster alveolar macrophages in vitro.
- Differences in the biokinetics of inhaled nano- versus micron-sized particles
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- A Comparative Dose-Related Response of Several Key Pro- and Antiinflammatory Mediators in the Lungs of Rats, Mice, and Hamsters After Subchronic Inhalation of Carbon Black
- Silicosis and coal workers' pneumoconiosis.
- Deposition, retention, and clearance of inhaled particles.
- Interspecies comparison of rat and hamster alveolar macrophage antioxidative and oxidative capacity.
- Dust overloading of the lungs: update and appraisal.
Cited by
- Pulmonary toxicity in rats following inhalation exposure to poorly soluble particles of low toxicity: Testing at excessive concentrations overwhelming lung clearance?
- Response to letter to editor "Pulmonary toxicity in rats following inhalation exposure to poorly soluble particles of low toxicity: Testing at excessive concentrations overwhelming lung clearance"?
- Expert workshop on the hazards and risks of poorly soluble low toxicity particles
- Airborne particle pollution predictive model using Gated Recurrent Unit (GRU) deep neural networks
- The REACH Registration Process: A Case Study of Metallic Aluminium, Aluminium Oxide and Aluminium Hydroxide.
- Risk assessment of components in tobacco smoke and e-cigarette aerosols: a pragmatic choice of dose metrics
- Utilizing literature-based rodent toxicology data to derive potency estimates for quantitative risk assessment
- An Integrated Approach to Testing and Assessment to Support Grouping and Read-Across of Nanomaterials After Inhalation Exposure
- Olivine Dissolution in Simulated Lung and Gastric Fluid as an Analog to the Behavior of Lunar Particulate Matter Inside the Human Respiratory and Gastrointestinal Systems
- Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model
- Towards health-based nano reference values (HNRVs) for occupational exposure: Recommendations from an expert panel
- Toxicology of lunar dust in the aspect of possible occupational pathology of astronauts participating in an expedition to the Moon (review)
- Carcinogenicity of Poorly Soluble Low Toxicity Particles: Commentary on Epidemiology as a Risk Assessment “Reality Check”
- No evidence for carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model
- Numerical investigations of the micro lunar dust particles deposition in the human oral respiratory airway.
- Issues in the inhalation toxicity testing and hazard assessment for low density particulate materials such as synthetic amorphous silica (SAS).
- P17-11: Poorly soluble low toxicity (PSLT) particles modulate genes related to inflammation and cancer development to a greater extent in rat than in mouse alveolar macrophages
- The reactivity of experimentally reduced lunar regolith simulants: Health implications for future crewed missions to the lunar surface
- Biodistribution of cerium dioxide and titanium dioxide nanomaterials in rats after single and repeated inhalation exposures
- Inflammation related to inhalation of nano and micron sized iron oxides: a systematic review
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