Beyond Genes: Re-Identifiability of Proteomic Data and Its Implications for Personalized Medicine
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Summary
This paper tries to differentiate proteomics from genomics data and cover the ethical challenges related to proteomics data sharing and gives an overview of the proposed solutions and the outlook for future studies.
- Type
- review
- Published
- 2019-09-01
- Cited by
- 30
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W2971887954
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:201869032
Keywords
Proteomics, Identifiability, Data sharing, Genomics, Data science
References
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- Ethical Legal and Social Issues of Biobanking: Past, Present, and Future
- Comparison of protein expression levels and proteomically-inferred genotypes using human hair from different body sites.
- PPLine: An Automated Pipeline for SNP, SAP, and Splice Variant Detection in the Context of Proteogenomics.
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- Detection of Unknown Amino Acid Substitutions Using Error-Tolerant Database Search.
- Privacy in the Genomic Era
- Privacy and Property in the Biobank Context
- Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data.
- Comparison of Protein Immunoprecipitation-Multiple Reaction Monitoring with ELISA for Assay of Biomarker Candidates in Plasma
- Children and biobanks: a review of the ethical and legal discussion
- Resolving Individuals Contributing Trace Amounts of DNA to Highly Complex Mixtures Using High-Density SNP Genotyping Microarrays
- Deterministic identification of specific individuals from GWAS results
- Deep Proteome Coverage Based on Ribosome Profiling Aids Mass Spectrometry-based Protein and Peptide Discovery and Provides Evidence of Alternative Translation Products and Near-cognate Translation Initiation Events*
- Reproducible quantitative proteotype data matrices for systems biology
- aLFQ: an R-package for estimating absolute protein quantities from label-free LC-MS/MS proteomics data
- The return of individual research findings in paediatric genetic research
- PEPPI: a peptidomic database of human protein isoforms for proteomics experiments
- Identification of a Novel Proteoform of Prostate Specific Antigen (SNP-L132I) in Clinical Samples by Multiple Reaction Monitoring*
- Large-scale quantification of single amino-acid variations by a variation-associated database search strategy.
Cited by
- Realizing the potential of blockchain technologies in genomics
- Comprehensive Detection of Single Amino Acid Variants and Evaluation of Their Deleterious Potential in a PANC-1 Cell Line
- The hunt for sORFs: A multidisciplinary strategy.
- Mass spectrometry-based identification and characterization of human hypothetical proteins highlighting the inconsistency across the protein databases
- Ethical Principles, Constraints, and Opportunities in Clinical Proteomics
- Data Management of Sensitive Human Proteomics Data: Current Practices, Recommendations, and Perspectives for the Future
- Wastewater Monitoring Raises Privacy and Ethical Considerations
- Individual Reference Intervals for Personalized Interpretation of Clinical and Metabolomics Measurements
- Towards Building a Quantitative Proteomics Toolbox in Precision Medicine: A Mini-Review
- Recommendations for Creating Codes of Conduct for Processing Personal Data in Biobanking Based on the GDPR art.40
- Associations between the Willingness to Donate Samples to Biobanks and Selected Psychological Variables
- Identifying individuals using proteomics: are we there yet?
- Serum proteomic analysis: role in the search for biomarkers of atherosclerosis
- Deep learning-driven fragment ion series classification enables highly precise and sensitive de novo peptide sequencing
- The ethical aspects of exposome research: a systematic review
- Advances in single-molecule junctions as tools for chemical and biochemical analysis
- Large scale proteomic studies create novel privacy considerations
- Tissue proteomics repositories for data reanalysis.
- Utilizing proteomics to identify and optimize microalgae strains for high-quality dietary protein: a review
- Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study
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