Methods to identify and optimize small molecules interacting with RNA (SMIRNAs)
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- Type
- review
- Published
- 2019-07-26
- Cited by
- 23
- References
- 98
- OpenAlex
- https://openalex.org/W2965489613
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:198984419
Keywords
RNA, Computational biology, Non-coding RNA, Long non-coding RNA, Small molecule
References
- Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus
- SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
- Selective small-molecule inhibition of an RNA structural element
- Lead- and drug-like compounds: the rule-of-five revolution.
- Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival
- Sequence-based design of bioactive small molecules that target precursor microRNAs
- SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
- Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure.
- A modified fluorescent intercalator displacement assay for RNA ligand discovery
- Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS
- Drug discovery beyond the 'rule-of-five'.
- Identifying the Preferred RNA Motifs and Chemotypes that Interact by Probing Millions of Combinations
- Two-Dimensional Combinatorial Screening (2DCS) of a Bacterial rRNA A-site-like Motif Library: Defining Privileged Asymmetric Internal Loops that Bind Aminoglycosides
- MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines
- ZINC: A Free Tool to Discover Chemistry for Biology
- Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix
- MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers
- RNA sequencing: advances, challenges and opportunities
- C9orf72 Nucleotide Repeat Structures Initiate Molecular Cascades of Disease
Cited by
- Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space.
- Precise Targeted Cleavage of a r(CUG) Repeat Expansion in Cells by Using a Small-Molecule–Deglycobleomycin Conjugate
- How We Think about Targeting RNA with Small Molecules
- Gini coefficients as a single value metric to define chemical probe selectivity
- Unnatural bases for recognition of noncoding nucleic acid interfaces
- Small molecule-RNA targeting: Starting with the fundamentals
- Recognition of small molecule–RNA binding sites using RNA sequence and structure
- Massively Parallel Optimization of the Linker Domain in Small Molecule Dimers Targeting a Toxic r(CUG) Repeat Expansion.
- Discovery of Surfactins as Inhibitors of MicroRNA Processing Using Cat-ELCCA.
- Bifacial PNAs Destabilize MALAT1 by 3′ A-Tail Displacement from the U-Rich Internal Loop
- Targeting riboswitches with beta-axial substituted cobalamins
- Targeting RNA with small molecules: lessons learned from Xist RNA
- Contemporary Progress and Opportunities in RNA-Targeted Drug Discovery.
- Pose prediction accuracy in ligand docking to RNA
- Comparative Assessment of Pose Prediction Accuracy in RNA-Ligand Docking
- MultiModRLBP: A Deep Learning Approach for Multi-Modal RNA-Small Molecule Ligand Binding Sites Prediction
- Advanced strategies for screening and identifying RNA-targeted small molecules: Bridging therapeutic potential and innovation
- 靶向嵌合体技术：靶向乳腺癌不可成药靶点的新工具
- Computational modeling of binding site for RNA-ligand complex by learning Multi-modal features
- Computational modeling of binding site for RNA-ligand complex by learning Multi-modal features
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