Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix
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Summary
In vivo decay assays indicate that this blunt-ended triple helix, with the 3′ nucleotide in a U•A-U triple, inhibits rapid nuclear RNA decay, which explains why triple-helical stacks longer than six do not occur in nature.
- Type
- article
- Published
- 2014-06-22
- Cited by
- 263
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W2032741347
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8041001
Keywords
Triple helix, RNA, Stem-loop, Biology, Chemistry
References
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- Poly(A) Tail Recognition by a Viral RNA Element Through Assembly of a Triple Helix
- Formation of triple-helical structures by the 3′-end sequences of MALAT1 and MENβ noncoding RNAs
- The Long Noncoding MALAT-1 RNA Indicates a Poor Prognosis in Non-small Cell Lung Cancer and Induces Migration and Tumor Growth
- Influence of sequence-dependent cytosine protonation and methylation on DNA triplex stability.
- Prediction of the stability of DNA triplexes.
- Structure of a triple helical DNA with a triplex-duplex junction.
- 3’ end processing of a long nuclear-retained non-coding RNA yields a tRNA-like cytoplasmic RNA
- Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function.
- MALAT-1: a long non-coding RNA and its important 3' end functional motif in colorectal cancer metastasis.
- Long noncoding RNA: an emerging paradigm of cancer research
- RNA tertiary interactions in the large ribosomal subunit: The A-minor motif
- Mutational analysis of a viral RNA element that counteracts rapid RNA decay by interaction with the polyadenylate tail
- Electrostatic effects in DNA triple helices.
- General plasmids for producing RNA in vitro transcripts with homogeneous ends.
- Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo
- A Kaposi's sarcoma virus RNA element that increases the nuclear abundance of intronless transcripts
Cited by
- Natural antisense RNA promotes 3′ end processing and maturation of MALAT1 lncRNA
- Long noncoding RNAs: Re-writing dogmas of RNA processing and stability
- New insights into the expression and functions of the Kaposi’s sarcoma-associated herpesvirus long noncoding PAN RNA
- The ins and outs of lncRNA structure: How, why and what comes next?
- Combinatorial control of Drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteins
- Towards structural classification of long non-coding RNAs
- Designing optogenetically controlled RNA for regulating biological systems
- Long non-coding RNA growth arrest-specific transcript 5 is involved in ovarian cancer cell apoptosis through the mitochondria-mediated apoptosis pathway.
- Long noncoding RNAs in viral infections
- MALAT1 long non-coding RNA in cancer.
- Long Non-Coding RNAs in Cancer and Development: Where Do We Go from Here?
- Large noncoding RNAs are promising regulators in embryonic stem cells.
- Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications
- Viral noncoding RNAs: more surprises
- Long noncoding RNA turnover
- PAN’s Labyrinth: Molecular Biology of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) PAN RNA, a Multifunctional Long Noncoding RNA
- The building process of the functional paraspeckle with long non-coding RNAs.
- Long Non-Coding RNA Regulation of Reproduction and Development
- From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease.
- Transposable elements and G-quadruplexes
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