Identification of Metabolites Identical and Similar to Drugs as Candidates for Metabolic Engineering.
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Summary
A pipeline to automatically search for metabolites available in the metabolic space that are structurally similar to worldwide approved drugs that were identified as similar to many drugs like Cabergoline, Oxitropium, Paclitaxel and had their metabolic pathways computationally mapped for their production in Saccharomyces cerevisiae with the proprietary pathway design software.
- Type
- article
- Published
- 2019-06-26
- Cited by
- 1
- References
- 58
- OpenAlex
- https://openalex.org/W2955653619
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:195765741
Keywords
Metabolic engineering, Context (archaeology), Computational biology, Biochemical engineering, Identification (biology)
References
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- Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis.
- PathPred: an enzyme-catalyzed metabolic pathway prediction server
- Efficient Heuristics for Maximum Common Substructure Search
- Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
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- Taxol biosynthesis: Taxane 13α-hydroxylase is a cytochrome P450-dependent monooxygenase
- Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production.
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