Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
Explore this paper's citation graph
Summary
Using PCR-amplified binding analysis, it is demonstrated that ADD1/SREBP1 has dual DNA sequence specificity, binding to both an E-box motif (ATCACGTGA) and a non-E-box sequence previously shown to be important in cholesterol metabolism, sterol regulatory element 1 (SRE-1).
- Type
- article
- Published
- 1995-05-01
- Cited by
- 340
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W1793348193
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10443985
Keywords
Sterol regulatory element-binding protein, Biology, Basic helix-loop-helix, Transcription factor, Biochemistry
References
- Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD.
- Transcriptional activation by heterodimers of the achaete‐scute and daughterless gene products of Drosophila.
- Structure and function of the b/HLH/Z domain of USF.
- Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
- Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation.
- Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain
- Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins.
- extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins.
- Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.
- Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer.
- MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer.
- Sequence-specific DNA binding by the c-Myc protein.
- Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection.
- SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.
- daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex.
- High basal expression and 3,5,3'-triiodothyronine regulation of messenger ribonucleic acid S14 in lipogenic tissues.
- SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.
- TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif.
- Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.
- ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
Cited by
- Transcriptional regulation of hepatic fatty acid metabolism.
- Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action*
- Genomic structure and chromosomal mapping of the human Site-1 protease (S1P) gene
- Insulin and Sterol-regulatory Element-binding Protein-1c (SREBP-1C) Regulation of Gene Expression in 3T3-L1 Adipocytes
- Connecting protein structure with predictions of regulatory sites
- Molecular cloning and expression of chicken carbohydrate response element binding protein and Max-like protein X gene homologues
- Diet-induced circadian enhancer remodeling synchronizes opposing hepatic lipid metabolic processes
- Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis.
- Rôle des facteurs de transcription SREBP-1 dans la fonction musculaire : implication des répresseurs transcriptionnels BHLHB2 et BHLHB3
- Sterol regulatory element binding proteins: their role in the hypoxic response of cancer cells and their regulation by the Akt/mTORC1 pathway
- Evolutionary history and diversification of duplicated fatty-acyl elongase genes of Atlantic salmon (Salmo salar)
- Transcriptional Regulation During Adipocyte Differentiation: A Role for SWI/SNF Chromatin Remodeling Enzymes: A Dissertation
- The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid traders.
- New Insights into How Adipocytes Sense their Triglyceride Stores. Is Cholesterol a Signal?
- The Role of the Liver X Receptor (LXR) in the Fetal Programming of Hepatic Gluconeogenesis
- Expression et fonction de l’adiponutrine/PNPLA3 dans le foie : Relation entre la voie Wnt/β-caténine, la sensibilité à l’insuline et la stéatose hépatique
- 転写因子 Sterol Regulatory Element-Binding Protein (SREBP) と糖質・脂質代謝
- An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression
- Inhibition of Mammalian Target of Rapamycin (mTOR) in Epidermis
- The Effects of Daecheongryong-tang on Transcription Factors and Adipogenic Genes during 3T3-L1 Differentiation
Related papers
- The Sterol Regulatory Element Binding Transcription Factor 1 (SREBP1): An AttractiveTherapeutic Target in CNS Drug Discoveries
- Fungal SREBPs: Hypoxic Transcription Factors Required for Pathogenesis
- Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix–Loop–Helix Transcription Factors
- Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor
- SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
- SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.
- Helix-loop-helix transcription factors mediate activation and repression of the p75LNGFR gene
- A Role for Sp and Helix-Loop-Helix Transcription Factors in the Regulation of the Human Id4 Gene Promoter Activity*
- MiT Family Transcriptional Factors in Immune Cell Functions
- E-box activator of the C4 promoter is related to but distinct from the transcription factor upstream stimulating factor.