Collateral Sensitivity of Parthenolide via NF-κB and HIF-α Inhibition and Epigenetic Changes in Drug-Resistant Cancer Cell Lines
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Summary
Analysis of gene expression profiles revealed NF-κB and HIF signaling as top networks of these genes, cellular functions and canonical pathways influencing the activity of PT against tumor cells, suggesting PT as novel candidate for cancer treatment.
- Type
- article
- Published
- 2019-05-21
- Cited by
- 37
- References
- 116
- Access
- Open access
- OpenAlex
- https://openalex.org/W2945942036
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:159042188
Keywords
Parthenolide, Cell culture, Chemistry, IκB kinase, Epigenetics
References
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- Mechanisms of resistance to EGFR tyrosine kinase inhibitors
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- Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib
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- The Synergistic Effect of SAHA and Parthenolide in MDA‐MB231 Breast Cancer Cells
- Expression of the breast cancer resistance protein in breast cancer.
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- The cross-talk between NF-kappaB and HIF-1: further evidence for a significant liaison.
- NF-kappaB in cancer: a marked target.
- Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats
- Chemotherapy-induced resistance by ATP-binding cassette transporter genes.
Cited by
- Inhibition of HIF-1α through Suppression of NF-κB Activation by Compounds Isolated from Senecio graveolens
- Repurposing Old Drugs into New Epigenetic Inhibitors: Promising Candidates for Cancer Treatment?
- Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells
- Medicinal plants and phytochemicals against multidrug-resistant tumor cells expressing ABCB1, ABCG2, or ABCB5: a synopsis of 2 decades
- Vitamin K3 chloroderivative (VKT-2) inhibits HDAC6, activates autophagy and apoptosis and inhibits aggresome formation in hepatocellular carcinoma cells.
- Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma
- Comparison of anticarcinogenic properties of Viburnum opulus and its active compound p-coumaric acid on human colorectal carcinoma
- Epidrug Repurposing: Discovering New Faces of Old Acquaintances in Cancer Therapy
- Development of Potential Antitumor Agents from the Scaffolds of Plant-derived Terpenoid Lactones
- Natural products in the reprogramming of Cancer epigenetics.
- Anticancer activities of parthenolide in primary effusion lymphoma preclinical models
- A novel moniliformin derivative as pan-inhibitor of histone deacetylases triggering apoptosis of leukemia cells.
- Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance
- Comparative differential cytotoxicity of clinically used SERMs in human cancer lines of different origin and its predictive molecular docking studies of key target genes involved in cancer progression and treatment responses
- Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties
- Transcriptomics, molecular docking, and cross-resistance profiling of nobiletin in cancer cells and synergistic interaction with doxorubicin upon SOX5 transfection.
- In Silico and In Vitro Screening of 50 Curcumin Compounds as EGFR and NF-κB Inhibitors
- The Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy
- Application of two-dimensional difference gel electrophoresis to identify protein changes between center, margin, and adjacent non-tumor tissues obtained from non-small-cell lung cancer with adenocarcinoma or squamous cell carcinoma subtype
- Novel epigenetic therapeutic strategies and targets in cancer.
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