Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell
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Summary
Single-cell RNA sequencing is applied to profile the regenerating mouse intestine and identified a distinct, damage-induced quiescent cell type that is mobilized by damage to revive the homoeostatic stem cell compartment and regenerate the intestinal epithelium, the revival stem cell (revSC).
- Type
- article
- Published
- 2019-04-24
- Cited by
- 490
- References
- 47
- OpenAlex
- https://openalex.org/W2941492678
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:129944961
Keywords
LGR5, Stem cell, Biology, Cell biology, Paneth cell
References
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- A renaissance for the pioneering 16S rRNA gene.
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- Cell cycle heterogeneity and plasticity of colorectal cancer stem cells
- Yap in regeneration and symmetry breaking
- Fasting reduces intestinal radiotoxicity enabling dose-escalated radiotherapy for pancreatic cancer
- YAP and TAZ: a signalling hub of the tumour microenvironment
- Cellular mechanisms of epithelial stem cell self‐renewal and differentiation during homeostasis and repair
- Cell-type diversity and regionalized gene expression in the planarian intestine revealed by laser-capture microdissection transcriptome profiling
- Yap1-driven intestinal repair is controlled by group 3 innate lymphoid cells
- Life or Death after a Break: What Determines the Choice?
- Time after time: circadian clock regulation of intestinal stem cells
- Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development
- Innate lymphoid cells and cholesterol metabolism in intestinal barrier function
- Use of organoids to study regenerative responses to intestinal damage.
- Rapidly cycling stem cells regenerate the intestine independent of Lgr5high cells
- Impaired renal gluconeogenesis is a major determinant of acute kidney injury associated mortality
- Niche-inspired synthetic matrices for epithelial organoid culture
- Intestinal Stem Cell Aging: Origins and Interventions.
- Implications for Tumor Microenvironment and Epithelial Crosstalk in the Management of Gastrointestinal Cancers
- Hippo-Yap/Taz signaling: Complex network interactions and impact in epithelial cell behavior
- Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis
- Patient-Derived Colorectal Cancer Organoids Upregulate Revival Stem Cell Marker Genes Following Chemotherapeutic Treatment
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