Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis
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Summary
It is shown that IPA blocks Trp biosynthesis in M. tuberculosis via inhibition of TrpE by mimicking the physiological allosteric inhibitor of this enzyme.
- Type
- article
- Published
- 2019-03-26
- Cited by
- 83
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W2924177015
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:85531918
Keywords
Metabolite, Indole test, Mycobacterium tuberculosis, Tryptophan, Allosteric regulation
References
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- Repurposing the Chemical Scaffold of the Anti‐Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis
- Susceptibility of Legionella pneumophila grown extracellularly and in human monocytes to indole-3-propionic acid
- Probability-based protein identification by searching sequence databases using mass spectrometry data
- Tryptophan biosynthesis protects mycobacteria from CD4 T cell-mediated killing
- In-gel digestion for mass spectrometric characterization of proteins and proteomes
- Tryptophan Uptake By Mycobacterium tuberculosis H37Rv: Effect of Rifampin and Ethambutol
- Tryptophan biosynthesis in Nicotiana tabacum and Daucus carota cell cultures: site of action of inhibitory tryptophan analogs.
- Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner
- Purification and characterization of anthranilate synthase component I (TrpE) from Mycobacterium tuberculosis H37Rv.
- The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, l-tryptophan
- Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4
- New use of BCG for recombinant vaccines
- AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility
- Indole‐3‐propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus
- Optimized Method for Preparation of DNA from Pathogenic and Environmental Mycobacteria
Cited by
- Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes
- Mycobacterial tryptophan biosynthesis: A promising target for tuberculosis drug development?
- Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome
- Metagenomics: aid to combat antimicrobial resistance in diarrhea
- The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty?
- Mycobacterium tuberculosis, antimicrobials, immunity, and lung–gut microbiota crosstalk: current updates and emerging advances
- Bioconversion of Biologically Active Indole Derivatives with Indole-3-Acetic Acid-Degrading Enzymes from Caballeronia glathei DSM50014
- Human microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs
- Synthesis, Characterization and Antibacterial Activity Evaluation of New Indole-Based Derivatives
- Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of Host–Microbe Tryptophan Metabolism
- An Army Marches on Its Stomach: Metabolic Intermediates as Antimicrobial Mediators in Mycobacterium tuberculosis Infection
- The tryptophan biosynthetic pathway is essential for Mycobacterium tuberculosis to cause disease
- Targeting immunometabolism in host defence against Mycobacterium tuberculosis
- Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties
- Dietary resistant starch preserved through mild extrusion of grain alters fecal microbiome metabolism of dietary macronutrients while increasing immunoglobulin A in the cat
- The infection-tolerant mammalian reservoir of Lyme disease and other zoonoses broadly counters the inflammatory effects of endotoxin
- A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity
- Targeting amino acid metabolism of Mycobacterium tuberculosis for developing inhibitors to curtail its survival
- Characteristic gut microbiota and metabolic changes in patients with pulmonary tuberculosis
- Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis
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