Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis
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Summary
These indole-4-carboxamides act as prodrugs of a tryptophan antimetabolite, 4-aminoindole, and are identified as a potential drug target for new anti-TB drugs.
- Type
- article
- Published
- 2021-03-13
- Cited by
- 16
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W3138164824
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:232366715
Keywords
Indole test, Tryptophan synthase, Tryptophan, Mycobacterium tuberculosis, Prodrug
References
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- Steady-state kinetics of indole-3-glycerol phosphate synthase from Mycobacterium tuberculosis.
- Allosteric Regulation of Substrate Channeling and Catalysis in the Tryptophan Synthase Bienzyme Complex
- Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor
- Designing novel spectral classes of proteins with a tryptophan-expanded genetic code
- New use of BCG for recombinant vaccines
- The regulation of tryptophan biosynthesis in Pseudomonas aeruginosa
- Global replacement of tryptophan with aminotryptophans generates non-invasive protein-based optical pH sensors.
- Characterization of the putative tryptophan synthase beta-subunit from Mycobacterium tuberculosis.
- Variation among Genome Sequences of H37Rv Strains of Mycobacterium tuberculosis from Multiple Laboratories
Cited by
- An antitubercular prodrug leaves Mycobacterium tuberculosis facing a difficult choice, poisoning or starvation?
- 6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis
- Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
- Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis
- The implication of Mycobacterium tuberculosis-mediated metabolism of targeted xenobiotics
- A serum NMR metabolomic analysis of the Corynebacterium pseudotuberculosis infection in goats
- Identification and optimization of pyridine carboxamide-based scaffold as a drug lead for Mycobacterium tuberculosis
- Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
- Amino Acid Biosynthesis Inhibitors in Tuberculosis Drug Discovery
- 5-Fluoroindole Reduces the Bacterial Burden in a Murine Model of Mycobacterium tuberculosis Infection
- Selective Inhibition Mechanism of Mycobacterium tuberculosis Tryptophan-tRNA Synthetase by Chuangxinmycin.
- The Quantification of Drug Accumulation within Gram-Negative Bacteria
- Design and synthesis of novel spirocyclic oxindole based hybrid scaffolds: in silico docking approach towards therapeutic target exploration
- The Quantification of Drug Accumulation within Gram-Negative Bacteria
- Systematic evaluation of computational tools to predict the effects of mutations on protein-ligand binding affinity in the absence of experimental structures
- Synthesis of 4-Aminoindole-Containing Cephalosporin Prodrugs and Their Biological Activity against Mycobacterium tuberculosis
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