Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Explore this paper's citation graph
Summary
A large genome-wide association meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.
- Type
- review
- Published
- 2019-02-28
- Cited by
- 2,451
- References
- 208
- Access
- Open access
- OpenAlex
- https://openalex.org/W2916749909
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:71144900
Keywords
Biology, Immunity, Disease, Genetics, Alzheimer's disease
References
- Characterization of single-nucleotide polymorphisms in coding regions of human genes
- SIFT: predicting amino acid changes that affect protein function
- Population Structure and Eigenanalysis
- WWOX gene is associated with HDL cholesterol and triglyceride levels
- A Genome-Wide Association Study on Obesity and Obesity-Related Traits
- Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
- Genetically Predicted Body Mass Index and Alzheimer’s Disease Related Phenotypes in Three Large Samples: Mendelian Randomization Analyses
- Gene Ontology Consortium: going forward
- Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance
- WW domain-containing oxidoreductase in neuronal injury and neurological diseases
- A multi-centre study of ACE and the risk of late-onset Alzheimer’s disease
- Comprehensive comparison of large-scale tissue expression datasets
- Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population‐based perspective
- Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes.
- Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs
- Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
- Maximum Entropy Modeling of Short Sequence Motifs with Applications to RNA Splicing Signals
- Neuroinflammation in the Aging Down Syndrome Brain; Lessons from Alzheimer's Disease
- Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Is Not a Major Determining Factor in the Development of Sporadic Alzheimer Disease: Evidence from an Updated Meta-Analysis
- Association of polymorphisms in the Angiotensin-converting enzyme gene with Alzheimer disease in an Israeli Arab community.
Cited by
- Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs
- Alzheimer disease and Apolipoprotein E4: meningeal brain lymphatics point to new clues in pathogenesis
- HDL from an Alzheimer's disease perspective
- Evaluation of CD33 as a Genetic Risk Factor for Alzheimer’s Disease
- Weighted burden analysis of exome-sequenced late onset Alzheimer’s cases and controls provides further evidence for involvement of PSEN1 and demonstrates protective role for variants in tyrosine phosphatase genes
- The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?
- Alzheimer’s patient brain myeloid cells exhibit enhanced aging and unique transcriptional activation
- Immune Signaling in Neurodegeneration
- Improvements of symptoms of Alzheimer`s disease by inhibition of the angiotensin system.
- Sex-dependent polygenic effects on the clinical progressions of Alzheimer’s disease
- SORL1 genetic variants and Alzheimer disease risk: a literature review and meta-analysis of sequencing data
- Clustering by phenotype and genome-wide association study in autism
- The Role of Neuronal NLRP1 Inflammasome in Alzheimer’s Disease: Bringing Neurons into the Neuroinflammation Game
- Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ‐secretase modulators
- Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment
- Association of Alzheimer’s Disease Genetic Risk Loci with Cognitive Performance and Decline: A Systematic Review
- ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice
- RNA editing alterations in a multi-ethnic Alzheimer disease cohort converge on immune and endocytic molecular pathways.
- Mitochondrial Dysfunctions: A Thread Sewing Together Alzheimer's Disease, Diabetes, and Obesity
- Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
Related papers
- Hypothyroidism and levothyroxine therapy following bariatric surgery: a systematic review, meta-analysis, network meta-analysis, and meta-regression.
- Is intradialytic oral nutritional supplementation safe and effective on clinical outcomes? A systematic review with conventional meta-analysis and network meta-analysis.
- oEffects of aerobic training with and without progression on blood pressure in patients with type 2 diabetes: a systematic review with meta-analyses and meta-regressions.
- Interventions for ADHD in childhood and adolescence: A systematic umbrella review and meta-meta-analysis.