Ferroptosis as a target for protection against cardiomyopathy
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Summary
It is discovered and demonstrated that ferroptosis, a programmed iron-dependent cell death, as a mechanism in murine models of doxorubicin (DOX)- and ischemia/reperfusion (I/R)-induced cardiomyopathy and Mitochondria-targeted antioxidant MitoTEMPO significantly rescued DOX cardiopathy, supporting oxidative damage of mitochondria as a major mechanism in ferroPTosis-induced heart damage.
- Type
- article
- Published
- 2019-01-28
- Cited by
- 1,870
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W2914574872
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:59339979
Keywords
Heme oxygenase, Programmed cell death, Cardiomyopathy, Mitochondrion, Heme
References
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Cited by
- Targeting Ferroptosis by Polydopamine Nanoparticles Protects Heart against Ischemia/Reperfusion Injury.
- Broken hearts: Iron overload, ferroptosis and cardiomyopathy
- GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis
- GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis
- Influence of mitochondrial and systemic iron levels in heart failure pathology
- Phospholipid oxidation products in Ferroptotic Myocardial Cell Death.
- Ferroptosis is programmed by the coordinated regulation of glutathione and iron metabolism by BACH1
- Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
- MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
- Keeping heart homeostasis in check through the balance of iron metabolism
- Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases.
- Molecular mechanisms of ferroptosis and its role in cancer therapy
- Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity
- An alternative way to look at diffuse large B-cell lymphoma : the impact of frequent engagement of ReIB NF-κB subunit on cell survival and patient outcome
- Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease.
- Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis
- Guidelines for evaluating myocardial cell death.
- Population Dynamics in Cell Death: Mechanisms of Propagation
- Neurodegeneration with brain iron accumulation: Insights into the mitochondria dysregulation.
- Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro.
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