A dual role for autophagy in a murine model of lung cancer
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Summary
It is reported that tissue-specific inactivation of Atg5, essential for the formation of autophagosomes, markedly impairs the progression of KRasG12D-driven lung cancer, resulting in a significant survival advantage of tumour-bearing mice.
- Type
- article
- Published
- 2014-01-20
- Cited by
- 420
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012958260
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6364273
Keywords
Autophagy, ATG5, Carcinogenesis, Cancer research, Biology
References
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- Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration
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Cited by
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- Cigarette smoke-induced autophagy: a deadly association?
- The Autophagy Lysosomal Pathway and Neurodegeneration
- Measuring Autophagy in Stressed Cells
- Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A
- Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2
- Cross-cancer profiling of molecular alterations within the human autophagy interaction network
- Sorafenib-induced defective autophagy promotes cell death by necroptosis
- Development of Assays and Irreversible Inhibitors for ATG4B: A Key Cysteine Protease Implicated in the Process of Autophagy
- Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress
- Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth
- Immunosurveillance in esophageal carcinoma: The decisive impact of regulatory T cells
- Metabolomics strategy reveals therapeutical assessment of limonin on nonbacterial prostatitis.
- Modulation of inflammation by autophagy: Consequences for human disease
- Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer
- p53 in survival, death and metabolic health: a lifeguard with a licence to kill
- Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses
- Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers.
- Trial watch: Dendritic cell-based anticancer therapy
- Autophagy in cellular metabolism and cancer.
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