A dual role for autophagy in a murine model of lung cancer

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Summary

It is reported that tissue-specific inactivation of Atg5, essential for the formation of autophagosomes, markedly impairs the progression of KRasG12D-driven lung cancer, resulting in a significant survival advantage of tumour-bearing mice.

Type
article
Published
2014-01-20
Cited by
420
References
54
Access
Open access

Keywords

Autophagy, ATG5, Carcinogenesis, Cancer research, Biology

References

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