Structural basis of sterol recognition by human hedgehog receptor PTCH1
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Summary
A 3.4-Å cryo-EM structure of the human PTCH1 bound to ShhNC24II, a modified hedgehog ligand mimicking its palmitoylated form, reveals a possible route for sterol translocation across the lipid bilayer by PT CH1 and homologous transporters.
- Type
- preprint
- Published
- 2018-12-30
- Cited by
- 71
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W2908472954
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:91259867
Keywords
Patched, Hedgehog, Sonic hedgehog, PTCH1, Hedgehog signaling pathway
References
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- Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome
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- Hedgehog signalling in cancer formation and maintenance
- The Hedgehog Signaling Pathway: Where Did It Come From?
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- A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia
- Evidence for a role of vertebrate Disp1 in long-range Shh signaling
- Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein.
Cited by
- Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling
- Sphingomyelin suppresses Hedgehog signaling by restricting cholesterol accessibility at the ciliary membrane
- Hedgehog pathway activation through conformational blockade of the Patched sterol conduit
- Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
- Mechanistic insights into the generation and transduction of Hedgehog Signaling
- Tmed2 regulates Smoothened trafficking and Hedgehog signalling
- Cryo-EM structure of the Hedgehog release protein Dispatched
- DNA Methylation-based Signatures Classify Sporadic Pituitary Tumors According to Clinicopathological Features
- Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
- Structural basis for the HMGCR interaction with UBIAD1 mutants causing Schnyder corneal dystrophy
- Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis
- Combining high throughput and high quality for cryo-electron microscopy data collection
- Novel PTCH1 mutation in Gorlin-Goltz syndrome potentially altered interactions with lipid bilayer.
- Dispatched conformational dynamics couples transmembrane Na+ flux to release of lipid-modified Hedgehog signal
- Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
- Protective effect of sonic hedgehog against oxidized low-density lipoprotein-induced endothelial apoptosis: Involvement of NF-κB and Bcl-2 signaling
- Gorlin Syndrome: Recent Advances in Genetic Testing and Molecular and Cellular Biological Research
- Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit
- Cholesterol access in cellular membranes controls Hedgehog signaling
- Molecular insights into the Patched1 drug efflux inhibitory activity of panicein A hydroquinone: a computational study.
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