MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin
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Summary
Findings reveal a new role of miR-21 in attenuating diabetic cardiomyopathy by targeting gelsolin, and provide a molecular basis for developing a miRNA-based therapy against diabetic carduomyopathy.
- Type
- article
- Published
- 2018-09-04
- Cited by
- 86
- References
- 85
- Access
- Open access
- OpenAlex
- https://openalex.org/W2891701747
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52155951
Keywords
Diabetic cardiomyopathy, Medicine, Internal medicine, Cardiomyopathy, Gelsolin
References
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- Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells.
- Isolation, culture, and functional characterization of adult mouse cardiomyoctyes.
- Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus.
- MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy
- Letter by Connelly et al regarding article, "Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension".
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- Gelsolin Regulates Cardiac Remodeling After Myocardial Infarction Through DNase I–Mediated Apoptosis
- Global and societal implications of the diabetes epidemic
- Targeting caveolin-3 for the treatment of diabetic cardiomyopathy.
Cited by
- MiR-30c/PGC-1β protects against diabetic cardiomyopathy via PPARα
- Regulatory Mechanism of MicroRNA-145 in the Pathogenesis of Acute Aortic Dissection
- Clinical Value of Circulating Microribonucleic Acids miR-1 and miR-21 in Evaluating the Diagnosis of Acute Heart Failure in Asymptomatic Type 2 Diabetic Patients
- Nuclear miR-665 aggravates heart failure via suppressing phosphatase and tensin homolog transcription
- MicroRNAs in central nervous system diseases: a prospective role in regulating blood-brain barrier integrity
- Identification of ncRNA-Mediated Functions of Nucleus-Localized miR-320 in Cardiomyocytes
- Knockdown of long noncoding RNA GAS5 protects human cardiomyocyte-like AC16 cells against high glucose-induced inflammation by inhibiting miR-21-5p-mediated TLR4/NF-κB signaling
- MiR‐144 protects the heart from hyperglycemia‐induced injury by regulating mitochondrial biogenesis and cardiomyocyte apoptosis
- Potential Clinical Implications of miR-1 and miR-21 in Heart Disease and Cardioprotection
- Ketogenic Diet Ameliorates Cardiac Dysfunction via Balancing Mitochondrial Dynamics and Inhibiting Apoptosis in Type 2 Diabetic Mice
- miR-410-5p promotes the development of diabetic cardiomyopathy by suppressing PIM1-induced anti-apoptosis.
- Molecular biomarkers in diabetes mellitus (DM)
- Examination of the Effect of a 50-Hz Electromagnetic Field at 500 μT on Parameters Related With the Cardiovascular System in Rats
- The additive effects of obesity on myocardial microcirculation in diabetic individuals: a cardiac magnetic resonance first-pass perfusion study
- Effects of ambient ozone exposure on circulating extracellular vehicle microRNA levels in coronary artery disease patients
- Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review
- MicroRNA and ROS Crosstalk in Cardiac and Pulmonary Diseases
- Inhibition of miR-223 attenuates the NLRP3 inflammasome activation, fibrosis, and apoptosis in diabetic cardiomyopathy.
- Value of circulating miRNA-21 in the diagnosis of subclinical diabetic cardiomyopathy.
- Cardiovascular effects of biological versus conventional synthetic disease-modifying antirheumatic drug therapy in treatment-naïve, early rheumatoid arthritis
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