miR-410-5p promotes the development of diabetic cardiomyopathy by suppressing PIM1-induced anti-apoptosis.
Explore this paper's citation graph
Summary
It is demonstrated that miR-410-5p might be involved in the progression of DCM by targeting PIM1 and might be a promising therapeutic target for DCM in the future.
- Type
- article
- Published
- 2020-03-04
- Cited by
- 19
- References
- 35
- OpenAlex
- https://openalex.org/W3012156652
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:212628930
Keywords
Diabetic cardiomyopathy, PIM1, Biology, Diabetes mellitus, Gene knockdown
References
- miR-503 Is Involved in the Protective Effect of Phase II Enzyme Inducer (CPDT) in Diabetic Cardiomyopathy via Nrf2/ARE Signaling Pathway
- Subendocardial Systolic Dysfunction in Asymptomatic Normotensive Diabetic Patients.
- MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy
- Hypoxic preconditioning increases survival of cardiac progenitor cells via the pim-1 kinase-mediated anti-apoptotic effect.
- Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy.
- Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart.
- Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy
- Competitive Interactions Between Cells: Death, Growth, and Geography
- Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
- MicroRNA profiling unveils hyperglycaemic memory in the diabetic heart.
- Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor α.
- Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy
- Pim-1 Kinase Protects Mitochondrial Integrity in Cardiomyocytes
- Hyperglycemia-Induced Protein Kinase C β2 Activation Induces Diastolic Cardiac Dysfunction in Diabetic Rats by Impairing Caveolin-3 Expression and Akt/eNOS Signaling
- Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1
- MicroRNA-451 Exacerbates Lipotoxicity in Cardiac Myocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice Through Suppression of the LKB1/AMPK Pathway
- lncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy
- [The microRNAs as biomarkers: What prospects?]
- From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
- CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats
Cited by
- Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders
- Folic Acid Alleviates High Glucose and Fat-Induced Pyroptosis via Inhibition of the Hippo Signal Pathway on H9C2 Cells
- The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
- MicroRNA‐494 regulates high glucose‐induced cardiomyocyte apoptosis and autophagy by PI3K/AKT/mTOR signalling pathway
- The Molecular Mechanism of the TEAD1 Gene and miR-410-5p Affect Embryonic Skeletal Muscle Development: A miRNA-Mediated ceRNA Network Analysis
- Pim Kinases: Important Regulators of Cardiovascular Disease
- Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway
- The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy
- Transcriptome profile analysis in spinal cord injury rats with transplantation of menstrual blood-derived stem cells
- Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose
- The interregulatory circuit between non-coding RNA and apoptotic signaling in diabetic cardiomyopathy
- PIM1 enhances insulin secretion and inhibits ferroptosis of high glucose-induced pancreatic β-cells through strengthening PINK1/Parkin-mediated mitophagy via inactivating JNK/p38 signaling pathway.
- Non-coding RNA as a key regulator and novel target of apoptosis in diabetic cardiomyopathy: Current status and future prospects.
- From Type 2 Diabetes Mellitus To Diabetic Cardiomyopathy – A Systematic Review On The Role Of MicroRNA
- Biochemical study on microRNAs (miR-410, miR-133 and miR-582) in Egyptian type 1 diabetic patients
- Causal role of adipose tissue-derived adipokines in the pathogenesis of heart failure with preserved ejection fraction: experimental demonstration as the basis for clinical targeting
- Aberrant miR-410-5p expression occurs in human lumbar intervertebral disk degeneration and improves nucleus pulposus cell degeneration by targeting AIFM1.
- Additional file 1 of Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway
- Additional file 1 of Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway
- Circulating miRNAs Correlate With rIPC‐Induced Cardioprotection and Its Impairment in Diabetic Myocardial Infarction via AMPK Signalling
Related papers
- Abstract 5016: IL-6 influences PIM1 expression in renal cell carcinoma
- Targeting an IL-6/JAK/STAT/PIM1 pathway in renal cell carcinoma.
- 2-Arachidonoylglycerol Attenuates Myocardial Fibrosis in Diabetic Mice Via the TGF-β1/Smad Pathway
- 2-Arachidonoylglycerol Attenuates Fibrosis in Diabetic Mice via the TGF-β1/Smad Pathway
- Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy.
- Protective effect and possible mechanisms of salvianolate in diabetic cardiomyopathy
- Streptozotocin-Induced Type 1 and 2 Diabetes Mellitus Mouse Models Show Different Functional, Cellular and Molecular Patterns of Diabetic Cardiomyopathy
- The effects of exercise training on cardiac matrix metalloproteinases activity and cardiac function in mice with diabetic cardiomyopathy.
- AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy