MT1-MMP cooperates with KrasG12D to promote pancreatic fibrosis through increased TGF-β signaling
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Summary
It is shown that the bona fide collagenase MT1-MMP paradoxically contributes to fibrosis by increasing TGF-β signaling and that targeting MT1,MMP may thus help to mitigate fibrosis.
- Type
- article
- Published
- 2011-08-19
- Cited by
- 61
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2148558651
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23162714
Keywords
Hepatic stellate cell, Cancer research, KRAS, Pancreatic cancer, Matrix metalloproteinase
References
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- K-ras mutations in pancreatic ductal proliferative lesions.
- Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion.
- Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice.
- Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas
- Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.
- MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1.
- The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.
- Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas.
- A matrix metalloproteinase expressed on the surface of invasive tumour cells
- Induction of Smad1 by MT1‐MMP contributes to tumor growth
- Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-β Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis*
- Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
- Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
- Desmoplastic Reaction in Pancreatic Cancer: Role of Pancreatic Stellate Cells
- An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms
- MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.
- Rho-ROCK-Myosin Signaling Meditates Membrane Type 1 Matrix Metalloproteinase-induced Cellular Aggregation of Keratinocytes*
- Overexpression of TGF-β by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancer
- MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17.
Cited by
- BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo.
- TGF-β1/Smad signaling, MMP-14, and MSC markers in arterial injury: discovery of the molecular basis of restenosis.
- Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasis
- Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer
- SIBLINGs and SPARC families: their emerging roles in pancreatic cancer.
- Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer
- CD44 regulates pancreatic cancer invasion through MT1-MMP
- Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review
- Stroma and pancreatic ductal adenocarcinoma: an interaction loop.
- IL-13 Promotes Collagen Accumulation in Crohn’s Disease Fibrosis by Down-Regulation of Fibroblast MMP Synthesis: A Role for Innate Lymphoid Cells?
- Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression
- Pancreatic ductal adenocarcinoma: From genetics to biology to radiobiology to oncoimmunology and all the way back to the clinic.
- Pancreatic stellate cells and pancreas cancer: current perspectives and future strategies.
- Rhein, a Natural Anthraquinone Derivative, Attenuates the Activation of Pancreatic Stellate Cells and Ameliorates Pancreatic Fibrosis in Mice with Experimental Chronic Pancreatitis
- Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis
- Smarter drugs emerging in pancreatic cancer therapy.
- Paracrine Activation of Chemokine Receptor CCR9 Enhances The Invasiveness of Pancreatic Cancer Cells
- Membrane-type matrix metalloproteinases in pericellular proteolysis and melanoma cell invasion
- Snail cooperates with KrasG12D to promote pancreatic fibrosis
- Snail Cooperates with KrasG12D in vivo to Increase Stem Cell Factor and Enhance Mast Cell
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