VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not PDGF-BB/PDGFR-β play important roles in promoting immature and inflammatory intraplaque angiogenesis
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Summary
There was a highly positive correlation between the VI, MVD, macrophage content, and TNF-α level, and the levels of VEGF-A/VEGFR-2 and FGF-2/FGFR-1, however, no correlations were observed between PDG FR-β levels and the VI or MVD.
- Type
- article
- Published
- 2018-08-20
- Cited by
- 30
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2888552237
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52054381
Keywords
Angiogenesis, Fibroblast growth factor, Vascular endothelial growth factor, Platelet-derived growth factor receptor, Medicine
References
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- The Platelet Response to Tissue Injury
- Specific Matrix Metalloproteinases Play Different Roles in Intraplaque Angiogenesis and Plaque Instability in Rabbits
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- Inflammation and Atherosclerosis: Novel Insights Into Plaque Formation and Destabilization
- Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content.
- Diversity Within Pericytes
- Prediction of atherosclerotic plaque ruptures with high-frequency ultrasound imaging and serum inflammatory markers.
- Lipid oxidation products and oxidized low-density lipoproteins impair platelet-derived growth factor receptor activity in smooth muscle cells: implication in atherosclerosis
- Fibroblast growth factor 2 is a key determinant of vascular sprouting during bovine luteal angiogenesis.
- Peak radial and circumferential strain measured by velocity vector imaging is a novel index for detecting vulnerable plaques in a rabbit model of atherosclerosis.
- A Role for VEGF as a Negative Regulator of Pericyte Function and Vessel Maturation
- Gene delivery of soluble vascular endothelial growth factor receptor-1 (sFlt-1) inhibits intra-plaque angiogenesis and suppresses development of atherosclerotic plaque
- Macrophage-derived TNFα is an early component of the molecular cascade leading to angiogenesis in response to aortic injury
- Soluble VE-cadherin in rheumatoid arthritis patients correlates with disease activity: evidence for tumor necrosis factor α-induced VE-cadherin cleavage.
- Nonendothelial Mesenchymal Cell–Derived MCP-1 Is Required for FGF-2–Mediated Therapeutic Neovascularization: Critical Role of the Inflammatory/Arteriogenic Pathway
- Targeting FGFR/PDGFR/VEGFR Impairs Tumor Growth, Angiogenesis, and Metastasis by Effects on Tumor Cells, Endothelial Cells, and Pericytes in Pancreatic Cancer
- Immunohistochemical demonstration of enzymatically modified human LDL and its colocalization with the terminal complement complex in the early atherosclerotic lesion.
- Overexpression of ACE2 Enhances Plaque Stability in a Rabbit Model of Atherosclerosis
Cited by
- The Platelet Response to Tissue Injury
- Effects of Cervical Rotatory Manipulation (CRM) on Carotid Atherosclerosis Plaque in Vulnerability: A Histological and Immunohistochemical Study Using Animal Model
- Angiogenic abnormalities in diabetes mellitus: mechanistic and clinical aspects.
- bFGF blockade reduces intraplaque angiogenesis and macrophage infiltration in atherosclerotic vein graft lesions in ApoE3*Leiden mice
- Ghrelin attenuate cerebral microvascular leakage by regulating inflammation and apoptosis potentially via a p38 MAPK-JNK dependent pathway.
- Integration of transcriptomics and metabolomics reveals anlotinib-induced cytotoxicity in colon cancer cells.
- Targeting WEE1 Inhibits Growth of Breast Cancer Cells That Are Resistant to Endocrine Therapy and CDK4/6 Inhibitors
- P2Y12 receptor blockers are anti-inflammatory drugs inhibiting both circulating monocytes and macrophages including THP-1 cells
- 1α,25-Dihydroxyvitamin D3 Promotes Angiogenesis After Cerebral Ischemia Injury in Rats by Upregulating the TGF-β/Smad2/3 Signaling Pathway
- The role and mechanism of tetramethylpyrazine for atherosclerosis in animal models: A systematic review and meta-analysis
- Defining Characteristics of Angiogenesis Regulation in Advanced Human Carotid Plaques
- Causal feature selection using a knowledge graph combining structured knowledge from the biomedical literature and ontologies: a use case studying depression as a risk factor for Alzheimer’s disease
- Propranolol ameliorates retinopathy of prematurity in mice by downregulating HIF-1α via the PI3K/Akt/ERK pathway
- Evaluation of the Regenerative Potential of Platelet-Lysate and Platelet-Poor Plasma Derived from the Cord Blood Units in Corneal Wound Healing Applications: An In Vitro Comparative Study on Corneal Epithelial Cells
- Molecular Mechanisms Underlying Pathological and Therapeutic Roles of Pericytes in Atherosclerosis
- Serum Levels of VEGF-A and Its Receptors in Patients in Different Phases of Hemorrhagic and Ischemic Strokes
- The biophysical perspective of the vascular alteration due to angiogenesis and inflammation in population at risk of atherosclerosis
- Piezo1 (Piezo-Type Mechanosensitive Ion Channel Component 1)-Mediated Mechanosensation in Macrophages Impairs Perfusion Recovery After Hindlimb Ischemia in Mice
- Bioinformatics analysis of key pharmacological pathways of proanthocyanidins combined with allicin against atherosclerosis
- Tetramethylpyrazine and paeoniflorin combination (TMP-PF) inhibits angiogenesis in atherosclerosis via miR-126/VEGF/VEGFR2 signaling pathway
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