Investigating the molecular pharmacology of the short chain fatty acid receptor FFA2
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Summary
These studies showed that FFA2 agonist binding was defined by an essential interaction between the ligand carboxylate and an orthosteric Arg-His-Arg triad, and demonstrated that removal of the positive charge at this position produced a signalling-biased form of F FA2, in which only coupling to Gi G proteins was fully maintained.
- Type
- dissertation
- Published
- 2018-01-01
- Cited by
- 1
- References
- 275
- OpenAlex
- https://openalex.org/W2883152521
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:91489859
Keywords
Antagonist, Pharmacology, G protein-coupled receptor, Agonist, Receptor
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