Trimethyl Lock: A Multifunctional Molecular Tool for Drug Delivery, Cellular Imaging, and Stimuli‐Responsive Materials
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Summary
Easy synthesis and possible chemical adaption to several different triggers make TML a highly versatile module for the development of drug‐delivery systems, prodrug approaches, cell‐imaging tools, molecular tools for supramolecular chemistry, as well as smart stimuliresponsive materials.
- Type
- review
- Published
- 2018-07-18
- Cited by
- 28
- References
- 224
- OpenAlex
- https://openalex.org/W2808390024
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:47016209
Keywords
Drug delivery, Molecular imaging, Nanotechnology, Drug, Biophysics
References
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Cited by
- Rapid chemiexcitation of phenoxy-dioxetane luminophores yields ultrasensitive chemiluminescence assays
- Detection of esterase activity by chromogenic and fluorogenic probe based on an O-nitrobenzoxadiazole (O-NBD) unit.
- Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues.
- Carbonyl Sulfide (COS) Donor induced protein persulfidation protects against oxidative stress.
- Fluorogenic sensing of mitochondrial electron transferring dehydrogenase using a trimethyl lock quinone-linked hemicyanine
- Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials
- Temperature and Photo Dual-Stimuli Responsive Block Copolymer Self-Assembly Micelles for Cellular Controlled Drug Release.
- Degradable Redox-Responsive Polyolefins
- Bioresponsive nanomedicines based on dynamic covalent bonds.
- Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome
- Development of Camptothecin Nano-Prodrugs Based on Trimethyl Lock Groups Toward Selective Drug Release in Cancer Cells
- Fatty acids as molecular carriers in cleavable antifungal conjugates.
- A Novel Redox-Sensitive Drug Delivery System Based on Trimethyl-Locked Polycarbonate.
- Controlled Ring-Opening Polymerization of Macrocyclic Monomers Based on Ring-Opening/Ring-Closing Cascade Reaction.
- Design and Characterization of Prodrug-like Inhibitors for Preventing Glutamate Efflux through Reverse Transport.
- Prodrug Strategy to Address Impaired Oral Absorption of a Weakly Basic TYK2 Inhibitor Caused by a Gastric Acid-Reducing Agent.
- Click Chemistry Methodology: The Novel Paintbrush of Drug Design
- NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic
- Carrier-free nano-prodrugs for enhanced cancer therapy: stimuli-responsive design and applications
- Novel trimethyl lock-based prostate-specific membrane antigen targeted Conjugates: Design, synthesis, and biological activity evaluation.
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