New latent fluorophore for DT diaphorase.
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Summary
The design and synthesis of a novel latent fluorophore 3 for DT diaphorase based on the trimethyl lock effect and characterization of its enzymatic kinetics are described.
- Type
- article
- Published
- 2006-01-19
- Cited by
- 41
- References
- 26
- OpenAlex
- https://openalex.org/W1964642727
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26060703
Keywords
Fluorophore, Chemistry, Diaphorase, Reagent, Fluorescence
References
- A selective, cell-permeable optical probe for hydrogen peroxide in living cells.
- Rat liver cytosolic azoreductase. Electron transport properties and the mechanism of dicumarol inhibition of the purified enzyme.
- Properties and reaction mechanism of DT diaphorase from rat liver.
- Rhodamine-based compounds as fluorogenic substrates for serine proteinases.
- A Novel Bis‐aziridinylnaphthoquinone with Anti‐Solid Tumor Activity in which Induced Apoptosis is Associated with Altered Expression Of Bcl‐2 Protein
- Targeted drug delivery systems 6: Intracellular bioreductive activation, uptake and transport of an anticancer drug delivery system across intestinal Caco-2 cell monolayers.
- The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT)
- Correlation of reaction rate acceleration with rotational restriction. Crystal-structure analysis of compounds with a trialkyl lock
- Stereopopulation control. I. Rate enhancement in the lactonizations of 0-hydroxyhydrocinnamic acids.
- Efficient synthesis of 'redox-switched' naphthoquinone thiol-crown ethers and their biological activity evaluation.
- Protective role of ubiquinone in vitamin E and selenium‐deficient plasma membranes
- Cytosolic NAD(P)H:(Quinone‐acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol
- Stereopopulation control. 3. Facilitation of intramolecular conjugate addition of the carboxyl group.
- Blood glucose determination with the reduction of resazurin as a fluorometric indicator reaction.
- The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review.
- Spectrophotometric kinetic study and analytical implications of the glucose oxidase-catalyzed reduction of [MIII(LL)2Cl2]+ complexes by d-glucose (M=Os and Ru, LL=2,2′-bipyridine and 1,10-phenanthroline type ligands)
- Chromatographic detection using tris(2,2'-bipyridyl)ruthenium(III) as a fluorogenic electron-transfer reagent.
- Purified NAD(P)H-quinone oxidoreductase enhances the mutagenicity of dinitropyrenes in vitro.
- Cytosol-mediated reduction of resorufin: a method for measuring quinone oxidoreductase.
- Cross-linking and sequence specific alkylation of DNA by aziridinyl quinones. 2. Structure requirements for sequence selectivity.
Cited by
- Development of a sensitive long-wavelength fluorogenic probe for nitroreductase: a new fluorimetric indictor for analyte determination by dehydrogenase-coupled biosensors.
- Pro-fluorogenic Reductase Substrate for Rapid, Selective, and Sensitive Visualization and Detection of Human Cancer Cells that Overexpress NQO1
- Fluorescent chemosensors based on spiroring-opening of xanthenes and related derivatives.
- A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells.
- Detection of glucose via enzyme-coupling reaction based on a DT-diaphorase fluorescence probe.
- Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups
- Kinetic delay of cyclization/elimination-coupled enzyme assays: analysis and solution.
- Activatable Optical Probes for the Detection of Enzymes
- Synthesis of a new long-wavelength latent fluorimetric indicator for analytes determination in the DT-Diaphorase coupling dehydrogenase assay system.
- Self‐Immolative Bioluminogenic Quinone Luciferins for NAD(P)H Assays and Reducing Capacity‐Based Cell Viability Assays
- Shedding light by cancer redox-human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye.
- Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells
- Self‐Cleavable Bioluminogenic Luciferin Phosphates as Alkaline Phosphatase Reporters
- Redox-sensitive polymeric nanoparticles for drug delivery.
- Spectroscopic probes with changeable π-conjugated systems.
- Latent fluorophores based on a Mannich cyclisation trigger
- Use of a profluorophore for visualization of the rupture of capsules in self-healing coatings.
- Synthesis of bioreductive esters from fungal compounds.
- Synthesis and applications of Rhodamine derivatives as fluorescent probes.
- Trimethyl lock: A trigger for molecular release in chemistry, biology, and pharmacology
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