The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
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Summary
This review describes historical milestones in the initial characterization of the KEAP1-NRF2 system and provides a comprehensive overview of the molecular mechanisms governing the functions ofKEAP1 and NRF2, as well as their roles in physiology and pathology.
- Type
- review
- Published
- 2018-07-01
- Cited by
- 1,754
- References
- 267
- Access
- Open access
- OpenAlex
- https://openalex.org/W2799290037
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13742320
Keywords
KEAP1, Cytoprotection, Effector, Transcription factor, Cell biology
References
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- Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development.
- Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
- The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.
- Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators?
- Cul3-mediated Nrf2 ubiquitination and ARE activation are dependent on the partial molar volume at position 151 of Keap1
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
- A conserved region adjacent to the basic domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins.
- Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway
- Mechanisms and Functions of Nrf2 Signaling in Drosophila
- SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
- Identification of the interactive interface and phylogenic conservation of the Nrf2‐Keap1 system
- Disruption of KEAP1/CUL3/RBX1 E3‐ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer
- Central nervous system‐specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction
- Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.
- The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.
- Transcription Factor Nrf2 Plays a Pivotal Role in Protection against Elastase-Induced Pulmonary Inflammation and Emphysema1
- Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun
- NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer.
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- Experimental study of camptothecin combined with drug-eluting bead transarterial chemoembolization in the rabbit VX2 liver tumor model
- Promising hepatoprotective effects of lycopene in different liver diseases.
- Resveratrol: An overview of its anti‐cancer mechanisms
- Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
- The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones
- The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging
- Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane
- Oncogenic activation of Nrf2 by specific knockout of Nrf1α that acts as a dominant tumor repressor
- Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease
- Nrf2 activator for the treatment of kidney diseases
- Nrf1 is paved as a new strategic avenue to prevent and treat cancer, neurodegenerative and other diseases.
- Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective
- Zinc‐binding triggers a conformational‐switch in the cullin‐3 substrate adaptor protein KEAP1 that controls transcription factor NRF2
- Roles of the KEAP1‐NRF2 system in mammalian skin exposed to UV radiation
- The protective effect of low‐energy shock wave on testicular ischemia‐reperfusion injury is mediated by the PI3K/AKT/NRF2 pathway
- Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus
- Evaluation of 2-thiothiazolidine-4-carboxylic acid, a common metabolite of isothiocyanates as a potential biomarker of cruciferous vegetable intake
- Redox regulation of cell state and fate
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