Nrf2 activator for the treatment of kidney diseases
Explore this paper's citation graph
Summary
The Kelch‐like ECH‐associated protein 1‐nuclear factor erythroid 2‐related factor 2 (Keap1‐Nrf2) system has drawn much attention in recent years for its anti‐oxidative and anti‐inflammatory properties, and its pharmacological potential for treatment of kidney diseases is being widely investigated in both clinical and non‐clinical studies.
- Type
- review
- Published
- 2018-12-01
- Cited by
- 60
- References
- 71
- Access
- Open access
- OpenAlex
- https://openalex.org/W2890248806
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52814742
Keywords
Activator (genetics), Kidney, Medicine, Intensive care medicine, Computational biology
References
- GFR decline as an alternative end point to kidney failure in clinical trials: a meta-analysis of treatment effects from 37 randomized trials.
- Effect of zinc supplementation on microalbuminuria in patients with type 2 diabetes: a double blind, randomized, placebo-controlled, cross-over trial.
- A food effect study and dose proportionality study to assess the pharmacokinetics and safety of bardoxolone methyl in healthy volunteers
- Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2
- Targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid prevents murine lupus nephritis
- Cardiovascular disease and its relationship with chronic kidney disease.
- Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl
- Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality
- Direct comparison of the effects of valsartan and amlodipine on renal hemodynamics in human essential hypertension.
- The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease
- Antioxidant treatment and outcome of cortinarius orellanus poisoning: a case series
- Effect of a carbonaceous oral adsorbent on the progression of CKD: a multicenter, randomized, controlled trial.
- Active NF-E2-related Factor (Nrf2) Contributes to Keep Endothelial NO Synthase (eNOS) in the Coupled State
- The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia reperfusion injury in mice
- Elevated Urinary Albumin Excretion Is Associated With Impaired Arterial Dilatory Capacity in Clinically Healthy Subjects
- Amlodipine Reduces Inflammation despite Promoting Albuminuria in the Streptozotocin-Induced Diabetic Rat
- The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death.
- Utility and validity of estimated GFR-based surrogate time-to-event end points in CKD: a simulation study.
- Activating Nrf-2 Signaling Depresses Unilateral Ureteral Obstruction-Evoked Mitochondrial Stress-Related Autophagy, Apoptosis and Pyroptosis in Kidney
- Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.
Cited by
- Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage.
- Effect of Indoxyl Sulfate on the Repair and Intactness of Intestinal Epithelial Cells: Role of Reactive Oxygen Species’ Release
- Cullin-Ring ubiquitin ligases in kidney health and disease
- Molecular Mechanisms of Epigallocatechin-3-Gallate for Prevention of Chronic Kidney Disease and Renal Fibrosis: Preclinical Evidence
- Identification of novel Nrf2/Keap1 pathway mutations in pediatric acute lymphoblastic leukemia
- Influence of mineral water of well No. 3 of Semyanivka village of Poltava district of Poltava region (Ukraine) on the structural and functional state of the kidneys with experimental nephritis
- Genetic Variations in Nrf2-Keap1 Complex: A Step towards Understanding Cancer Resistance in Blind Mole Rats Cytotypes
- Hydrogen‐rich water alleviates cyclosporine A‐induced nephrotoxicity via the Keap1/Nrf2 signaling pathway
- MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium
- Roles of Nrf2 in Protecting the Kidney from Oxidative Damage
- The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?
- Mistimed H2S upregulation, Nrf2 activation and antioxidant proteins levels in renal tubular epithelial cells subjected to anoxia and reoxygenation.
- Bardoxolone methyl: drug development for diabetic kidney disease
- Alport Syndrome Classification and Management
- Current Landscape of NRF2 Biomarkers in Clinical Trials
- Genetic or Pharmacologic Nrf2 Activation Increases Proteinuria in Chronic Kidney Disease in Mice
- Protective Effects of Smilax glabra Roxb. Against Lead-Induced Renal Oxidative Stress, Inflammation and Apoptosis in Weaning Rats and HEK-293 Cells
- Protective effect of panaxydol against repeated administration of aristolochic acid on renal function and lipid peroxidation products via activating Keap1‐Nrf2/ARE pathway in rat kidney
- Amphora algae with low‐level ionizing radiation exposure ameliorate D‐galactosamine‐induced inflammatory impairment in rat kidney
- Nrf2: a dark horse in Alzheimer's disease treatment.
Related papers
- DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION
- Genentech taps Affimed’s antibodies
- KOMPLIKASI REGIONAL ANESTESI PADA PEDIATRIK
- Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria
- Cardiac retransplantation in children.
- Avaliacao hemodinamica sequencial em transplante de coracao
- Thoracoscopic discectomy and fusion in the treatment of spinal deformities
- [Hepatic retransplant and acute Budd Chiari syndrome. Case report].