The genetic landscape of Alzheimer disease.
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Summary
This work has identified more than 20 loci with common variability having small contributions to the susceptibility of AD, and the application of next-generation sequencing has begun to reveal the contribution of rarer variants with medium effects on risk for AD.
- Type
- review
- Published
- 2018-01-01
- Cited by
- 99
- References
- 115
- OpenAlex
- https://openalex.org/W2793416367
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3502495
Keywords
PSEN1, Disease, Apolipoprotein E, Biology, Dementia
References
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- Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes
- Impact of late-onset Alzheimer’s genetic risk factors on beta-amyloid endocytic production
- Cerebrospinal Fluid BACE1 Activity and sAβPPβ as Biomarker Candidates of Alzheimer’s Disease
- Neuroprotective Effects of Ginsenoside Rf on Amyloid-β-Induced Neurotoxicity in vitro and in vivo
- Lipid associated polygenic enrichment in Alzheimer’s disease
- Animal Models of Neurodegenerative Diseases
- Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease
- Early-onset Alzheimer Disease and Its Variants
- Late-onset Alzheimer Disease
- An Overview of Primary Dementias as Clinicopathological Entities
- Regulation of Neprilysin Activity and Cognitive Functions in Rats After Prenatal Hypoxia
- Neuronal aging potentiates beta-amyloid generation via amyloid precursor protein endocytosis
- A novel mutation in PSEN1 (p.T119I) in an Argentine family with early- and late-onset Alzheimer's disease.
- IPSC-derived neuronal cultures expressing the Alzheimer’s disease associated rare TREM2 R47H variant enables the construction of an Aβ-induced gene regulatory network
- MicroRNAs in Alzheimer’s Disease: Diagnostic Markers or Therapeutic Agents?
- Modeling Alzheimer’s disease with human iPS cells: advancements, lessons, and applications
- Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer’s Disease Risk?
- Assessing the psychological impact of genetic susceptibility testing: Where have we been, where do we go from here?
- Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
- Rationale for the development of an Alzheimer’s disease vaccine
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