Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain
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Summary
It is speculated that the glymphatic system may be the major contributory factor to the deposition and clearance of gadolinium in brain tissue and the mechanism for Gd deposition in the brain will be discussed.
- Type
- article
- Published
- 2018-01-25
- Cited by
- 93
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W2790746777
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4798040
Keywords
Glymphatic system, Perivascular space, Cerebrospinal fluid, Interstitial fluid, Medicine
References
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- Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent.
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- An immunocytochemical study of protein clearance in brain infusion edema
- Serial scans in healthy volunteers following intravenous administration of gadoteridol: time course of contrast enhancement in various cranial fluid spaces.
- Progressive Increase of T1 Signal Intensity of the Dentate Nucleus on Unenhanced Magnetic Resonance Images Is Associated With Cumulative Doses of Intravenously Administered Gadodiamide in Patients With Normal Renal Function, Suggesting Dechelation
- Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain
- Pathways of Fluid Drainage from the Brain ‐ Morphological Aspects and Immunological Significance in Rat and Man
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- Residual or retained gadolinium: practical implications for radiologists and our patients.
- Sleep Drives Metabolite Clearance from the Adult Brain
- A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
- Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging.
- Brain gadolinium deposition after administration of gadolinium-based contrast agents
- Signal Change in the Dentate Nucleus on T1-Weighted MR Images After Multiple Administrations of Gadopentetate Dimeglumine Versus Gadobutrol.
- Contribution of metals to brain MR signal intensity: review articles
Cited by
- Can low b value diffusion weighted imaging evaluate the character of cerebrospinal fluid dynamics?
- Do Gadolinium-Based Contrast Agents Affect 18F-FDG PET/CT Uptake in the Dentate Nucleus and the Globus Pallidus? A Pilot Study
- Methodological Aspects for Preclinical Evaluation of Gadolinium Presence in Brain Tissue
- Synthesis, Stability and Relaxivity of TEEPO-Met: An Organic Radical as a Potential Tumour Targeting Contrast Agent for Magnetic Resonance Imaging
- Update April 2018
- Linear gadolinium‐based contrast agent (gadodiamide and gadopentetate dimeglumine)‐induced high signal intensity on unenhanced T1‐weighted images in pediatric patients
- Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?
- Signal Intensity of the Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agents: Strong Contrast Enhancement around the Vein of Labbe
- Glymphatic Pathway of Gadolinium-Based Contrast Agents through the Brain: Overlooked and Misinterpreted
- Chemical Insights into the Issues of Gd Retention in the Brain and Other Tissues Upon the Administration of Gd-Containing MRI Contrast Agents
- Signal intensity increases in dentate nucleus/globus pallidus/pulvinar on unenhanced T1WI MR images after multiple examinations with gadodiamide
- Gadolinium Presence in the Brain After Administration of the Liver-Specific Gadolinium-Based Contrast Agent Gadoxetate: A Systematic Comparison to Multipurpose Agents in Rats.
- Gadoliniumablagerungen – Morbus Gadolinium
- Gadolinium Retention and Clearance in the Diabetic Brain after Administrations of Gadodiamide, Gadopentetate Dimeglumine, and Gadoterate Meglumine in a Rat Model
- Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting
- Impact of brain tumors and radiotherapy on the presence of gadolinium in the brain after repeated administration of gadolinium-based contrast agents: an experimental study in rats
- Glymphatic imaging using MRI
- Evaluation of 3.0-T MRI Brain Signal after Exposure to Gadoterate Meglumine in Women with High Breast Cancer Risk and Screening Breast MRI.
- Cisternostomy: A Timely Intervention in Moderate to Severe Traumatic Brain Injuries: Rationale, Indications, and Prospects.
- Gadolinium Deposition in the Brain and Body
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