4-Phenylbutyrate suppresses the unfolded protein response without restoring protein folding in Saccharomyces cerevisiae
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Summary
Observations indicate that at least in the case of yeast cells, 4-PBA suppresses the UPR not through restoration of the ER function to correctly fold proteins, but through the accelerated degradation of Ire1.
- Type
- article
- Published
- 2018-03-01
- Cited by
- 30
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2789632463
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3888867
Keywords
Unfolded protein response, Endoplasmic reticulum, Chemical chaperone, Phenylbutyrate, Saccharomyces cerevisiae
References
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- Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
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- A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- Modulation of deltaF508 cystic fibrosis transmembrane regulator trafficking and function with 4-phenylbutyrate and flavonoids.
- The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis.
- Suppressive effects of 4‐phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress
- Unfolding the role of protein misfolding in neurodegenerative diseases
- F-actin and a type-II myosin are required for efficient clustering of the ER stress sensor Ire1.
- Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
- Lipid‐Induced ER Stress: Synergistic Effects of Sterols and Saturated Fatty Acids
- Signalling pathways in the unfolded protein response: development from yeast to mammals.
- Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast.
- Biosynthesis of cystic fibrosis transmembrane conductance regulator.
- Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum*
- Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells.
- Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
- Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins.
- In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR.
Cited by
- Different construction strategies affected on the physiology of Pichia pastoris strains highly expressed lipase by transcriptional analysis of key genes
- Endoplasmic reticulum stress-mediated autophagy contributes to 5-ethylamino-9-diethylaminobenzo[a]phenoselenazinium-mediated photodynamic therapy via the PERK–eIF2α pathway
- Monitoring ADP/ATP ratio in yeast cells using the fluorescent-protein reporter PercevalHR
- Cellular stress due to impairment of collagen prolyl hydroxylation complex is rescued by the chaperone 4-phenylbutyrate
- The unfolded protein response alongside the diauxic shift of yeast cells and its involvement in mitochondria enlargement
- Dispersion of endoplasmic reticulum-associated compartments by 4-phenyl butyric acid in yeast cells.
- Improved production of recombinant Rhizomucor miehei lipase by coexpressing protein folding chaperones in Pichia pastoris, which triggered ER stress
- Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
- Regulation of Endoplasmic Reticulum Stress in Saccharomyces cerevisiae
- The unfolded protein response in Pichia pastoris without external stressing stimuli.
- In Vivo Imaging with Genetically Encoded Redox Biosensors
- Beyond Proteostasis: Lipid Metabolism as a New Player in ER Homeostasis
- The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress
- Induction and Aggravation of the Endoplasmic-Reticulum Stress by Membrane-Lipid Metabolic Intermediate Phosphatidyl-N-Monomethylethanolamine
- Induction of the Unfolded Protein Response at High Temperature in Saccharomyces cerevisiae
- Selective inhibition of protein secretion by abrogating receptor–coat interactions during ER export
- 4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson’s Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation
- 4‐phenylbutyric acid—Identity crisis; can it act as a translation inhibitor?
- Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands
- Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
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