Indoleamine 2, 3-dioxygenase regulation of immune response (Review).
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Summary
Evaluating how catabolism of tryptophan regulated by IDO modulates the immune response to inflammatory and immunological signals finds that blocking this pathway may be a novel adjuvant therapeutic strategy for clinical application in immunotherapy.
- Type
- review
- Published
- 2018-04-01
- Cited by
- 117
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W2789522113
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26293390
Keywords
Indoleamine 2,3-dioxygenase, Immune system, Biology, Catabolism, Effector
References
- IDO expressing dendritic cells suppress allograft rejection of small bowel transplantation in mice by expansion of Foxp3+ regulatory T cells.
- Possible role of the ‘IDO‐AhR axis’ in maternal‐foetal tolerance
- Indoleamine 2,3-dioxygenase (IDO) induced by Leishmania infection of human dendritic cells
- Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy
- The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells
- Indoleamine‐2,3‐dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B
- The specific targeting of immune regulation: T-cell responses against Indoleamine 2,3-dioxygenase
- 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival.
- Immuno-Regulatory Function of Indoleamine 2,3 Dioxygenase through Modulation of Innate Immune Responses
- Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival
- Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies
- Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
- IDO inhibits a tryptophan sufficiency signal that stimulates mTOR
- Indoleamine 2,3 dioxygenase and metabolic control of immune responses
- Metabolic Pathways in T Cell Fate and Function
- Prevention of allogeneic fetal rejection by tryptophan catabolism.
- Induction of regulatory T Cells by dendritic cells through indoleamine 2,3-dioxygenase: a potent mechanism of acquired peripheral tolerance.
- IDO-Competent-DCs Induced by IFN-γ Attenuate Acute Rejection in rat Liver Transplantation
- Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.
- Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice.
Cited by
- The Tumor Vascular Endothelium as Decision Maker in Cancer Therapy
- Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections.
- [Tryptophan and metabolic syndrome, a new challenge for health].
- Nicotinamide and Demographic and Disease transitions: Moderation is Best
- Immunoregulatory effect of mouse fetal neural cells on the graft-versus-host disease
- Assessment of neopterin and indoleamine 2,3‐dioxygenase activity in patients with seasonal influenza: A pilot study
- CXCR4 inhibition modulates the tumor microenvironment and retards the growth of B16-OVA melanoma and Renca tumors
- Functions of the WNT Signaling Network in Shaping Host Responses to Infection
- THE AUTOIMMUNE RESPONSE ELICITED BY MOUSE HEPATITIS VIRUS (MHV-A59) INFECTION IS MODULATED BY LIVER TRYPTOPHAN-2,3-DIOXYGENASE (TDO).
- Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season
- The therapeutic effect of dendritic cells expressing indoleamine 2,3-dioxygenase (IDO) on an IgA nephropathy mouse model
- Inhibition of antigen-specific immune responses by co-application of an indoleamine 2,3-dioxygenase (IDO)-encoding vector requires antigen transgene expression focused on dendritic cells
- Endothelial cell and T‐cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation
- New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission
- Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs.
- Electroporation as a method of choice to generate genetically modified dendritic cell cancer vaccines.
- Tolerizing Strategies for the Treatment of Autoimmune Diseases: From ex vivo to in vivo Strategies
- HIV-1 Tat – TLR4/MD2 interaction drives the expression of IDO-1 in monocytes derived dendritic cells through NF-κB dependent pathway
- COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status
- Tryptophan Metabolism, Inflammation, and Oxidative Stress in Patients with Neurovascular Disease
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