Indoleamine 2,3-dioxygenase (IDO) induced by Leishmania infection of human dendritic cells
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Summary
It is demonstrated that infection of human myeloid‐derived DC with L. major and L. donovani induces IDO expression using a mechanism that involves autocrine or paracrine stimulation with a DC‐secreted factor, suggesting that one mechanism Leishmania parasites utilize to circumvent immune clearance may be to promote the induction of IDO among host DC within the infection microenvironment.
- Type
- article
- Published
- 2012-10-01
- Cited by
- 25
- References
- 56
- OpenAlex
- https://openalex.org/W1705870922
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8485304
Keywords
Biology, Indoleamine 2,3-dioxygenase, Immune system, Immunology, Leishmania
References
- Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses.
- Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase
- Immune privilege in sites of chronic infection: Leishmania and regulatory T cells
- Infection of human monocytes by Leishmania results in a defective oxidative burst.
- Regulation of the immune system in metazoan parasite infections.
- Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.
- IL-12p70 Production by Leishmania major-Harboring Human Dendritic Cells Is a CD40/CD40 Ligand-Dependent Process
- Cell-mediated immunity in American visceral leishmaniasis: reversible immunosuppression during acute infection
- Activation of TGF-β by Leishmania chagasi: Importance for Parasite Survival in Macrophages 1
- Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells1
- The innate immune response against Leishmania parasites.
- Human malaria parasites in continuous culture.
- Ido expression by dendritic cells: tolerance and tryptophan catabolism
- RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by interferon–γ‐primed macrophages
- Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts.
- Inhibition of group B streptococcal growth by IFN gamma-activated human glioblastoma cells.
- Leishmaniasis: complexity at the host–pathogen interface
- T cell proliferation is blocked by indoleamine 2,3-dioxygenase.
- Interleukin-12 and the regulation of innate resistance and adaptive immunity
- On watching the watchers: IDO and type I/II IFN
Cited by
- Indoleamine 2,3-dioxygenase confers resistance to chemotherapy and γ radiation to cancer cells, independent of direct immune involvement
- Role of indoleamine 2,3-dioxygenase in health and disease.
- Human Dendritic Cells exhibit a pronounced type I IFN signature following Leishmania major infection that is required for IL-12 induction.
- Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes
- Benznidazole treatment reduces the induction of indoleamine 2,3‐dioxygenase (IDO) enzymatic activity in Chagas disease symptomatic patients
- Characterization of microRNA Expression Profiles in Leishmania Infected Human Phagocytes
- Drug analog inhibition of indoleamine 2,3‐dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection
- The Immunotherapeutic Role of Regulatory T Cells in Leishmania (Viannia) panamensis Infection
- Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism
- The kynurenine pathway and parasitic infections that affect CNS function.
- Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype
- Indoleamine 2, 3-dioxygenase regulation of immune response (Review).
- Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis
- Arginase and its mechanisms in Leishmania persistence
- Macrophages as host, effector and immunoregulatory cells in leishmaniasis: Impact of tissue micro-environment and metabolism
- Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis
- Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest
- Activities of plasma indoleamine-2, 3-dioxygenase (IDO) enzyme in Nigerian patients with lung diseases: basis for tryptophan supplementation or IDO inhibitor use
- Targeting Leishmania Promastigotes and Amastigotes Forms through Amino Acids and Peptides: A Promising Therapeutic Strategy.
- Immunoregulatory Enzymes
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