Environment dominates over host genetics in shaping human gut microbiota
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Summary
Genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment are examined, and it is demonstrated that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition.
- Type
- article
- Published
- 2018-02-28
- Cited by
- 2,441
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W2787902098
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3608904
Keywords
Microbiome, Biology, Metagenomics, Human microbiome, Microbial genetics
References
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Cited by
- The Gut Microbiota in the First Decade of Life.
- Genetics of irritable bowel syndrome
- Modeling the temporal dynamics of the gut microbial community in adults and infants
- The Human Gut Microbiome: From Association to Modulation.
- Host‐derived population genomics data provides insights into bacterial and diatom composition of the killer whale skin
- Host genetics and microbiome associations through the lens of genome wide association studies.
- Impact of early environmental exposures on the mouse gut microbiota and immune responses
- Characterisation of the UK honey bee (Apis mellifera) metagenome
- The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get
- A system biology perspective on environment-host-microbe interactions.
- Not only priming: Soil microbiota may protect tomato from root pathogens
- The Interplay Between the Microbiome and Cardiovascular Risk
- Introduction: The host‐associated microbiome: Pattern, process and function
- Gut microbiota derived metabolites in cardiovascular health and disease
- Efficacy of Combination Antibiotic Therapy for Refractory Pediatric Inflammatory Bowel Disease.
- Current evidence linking diet to gut microbiota and brain development and function
- Determinants of IBD Heritability: Genes, Bugs, and More.
- Explainable machine learning prediction of synergistic drug combinations for precision cancer medicine
- Composition and functional roles of the gut microbiota in mosquitoes
- Dysbiotic drift and biopsychosocial medicine: how the microbiome links personal, public and planetary health
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