Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins

Keywords

Genomics, Personal genomics, Judaism, Panel discussion, Population genomics

References

• Population Structure and EigenanalysisV. K. Lukyanov — 2006
• Whole population, genome-wide mapping of hidden relatedness.Ida Lundin — 2009
• Abraham's children in the genome era: major Jewish diaspora populations comprise distinct genetic clusters with shared Middle Eastern Ancestry.Abdul Rahman Rasho, Abdul Rahman — 2010
• Origins and Genetic Legacy of Neolithic Farmers and Hunter-Gatherers in EuropeН. А. Зеленский, А. П. Авдеенко, Г. В. Мокриков — 2012
• Coalescent Theory: An IntroductionJ Wakeley — 2008
• Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish populationSteven M. Bray, Jennifer G. Mullé, Anne Dodd — 2010
• Demographic history and rare allele sharing among human populationsSimon Gravel, Brenna M. Henn, Ryan N. Gutenkunst — 2011
• Analytical results on the neutral non-equilibrium allele frequency spectrum based on diffusion theory.Daniel Živković, Wolfgang Stephan — 2011
• Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA NanoarraysRadoje Drmanac, Andrew B. Sparks, Matthew J. Callow — 2010
• Properties and rates of germline mutations in humansCatarina D. Campbell, Evan E. Eichler — 2013
• Revising the human mutation rate: implications for understanding human evolutionAylwyn Scally, Richard Durbin — 2012
• ANNOVAR: functional annotation of genetic variants from high-throughput sequencing dataKai Wang, Man Li, Håkon Håkonarson — 2010
• Low-Pass Genome-Wide Sequencing and Variant Inference Using Identity-by-Descent in an Isolated Human PopulationAlexander Gusev, Minita Shah, Eimear E. Kenny — 2012
• Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human ExomesJacob A. Tennessen, Abigail W. Bigham, Timothy D. O’Connor — 2012
• A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association StudiesBryan Howie, Peter Donnelly, Jonathan Marchini — 2009
• The deleterious mutation load is insensitive to recent population historyYuval B. Simons, Michael C. Turchin, Jonathan K. Pritchard — 2013
• Mitochondrial DNA signals of late glacial recolonization of Europe from near eastern refugia.Maria Pala, Anna Olivieri, Alessandro Achilli — 2012
• Proportionally more deleterious genetic variation in European than in African populationsKirk E. Lohmueller, Amit Indap, Steffen Schmidt — 2008
• The genome-wide structure of the Jewish peopleDoron M. Behar, Bayazit Yunusbayev, Mait Metspalu — 2010
• Length distributions of identity by descent reveal fine-scale demographic history.Pier Francesco Palamara, Todd Lencz, Ariel Darvasi — 2012

Cited by

• Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individualsMufid Abudiab, Ahmed Mahdy — 2015
• Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish populationJosé María Rodríguez-Vigil Reguera — 2016
• GENETICS AND PATHOGENESIS OF INFLAMMATORY BOWEL DISEASETa‐Chiang Liu, Thaddeus S. Stappenbeck — 2016
• Genetic markers cannot determine Jewish descentRaphael Falk — 2015
• No evidence that selection has been less effective at removing deleterious mutations in Europeans than in AfricansRon Do, Daniel J. Balick, Heng Li — 2015
• Genetic contribution to multiple sclerosis risk among Ashkenazi JewsPouya Khankhanian, Takuya Matsushita, Lohith Madireddy — 2015
• Genetic movement disorders in patients of Jewish ancestry.Rivka Inzelberg, Sharon Hassin‐Baer, Joseph Jankovic — 2014
• GREM1 germline mutation screening in Ashkenazi Jewish patients with familial colorectal cancerYael Laitman, Emma Jaeger, Lior H. Katz — 2015
• Dissecting the Mechanisms Underlying Unusually Successful Human Healthspan and LifespanSofiya Milman, Nir Barzilai — 2015
• Jews and Non-Territorial Autonomy: Political Programmes and Historical PerspectivesRoni Gechtman — 2016
• An Ashkenazi founder mutation in the PKHD1 gene.Adina Quint, Michal Sagi, Shai Carmi — 2016
• Genetic affinities of the Jewish populations of IndiaGyaneshwer Chaubey, Manvendra Singh, Niraj Rai — 2016
• Tracing Sephardic Jewry Through Genetics: Crypto-Jews and the Second DiasporaMaria Inês Pires Nogueiro — 2015
• Expanded Genetic Screening Panel for the Ashkenazi Jewish PopulationBrett Baskovich, Susan Hiraki, Kinnari Upadhyay — 2015
• Expanding the phenotype of CRB2 mutations – A new ciliopathy syndrome?R. Jaron, Nitzan Rosenfeld, Fouad Zahdeh — 2016
• Applying Ancestry and Sex Computation as a Quality Control Tool in Targeted Next-Generation Sequencing.Patrick C. Mathias, Emily H. Turner, Sheena Scroggins — 2016
• Religiosity as a predictor of in-group favoritism within and between religious groupsCurtis S. Dunkel, Edward Dutton — 2016
• Rapidly Registering Identity-by-Descent Across Ancestral Recombination GraphsShuo Yang, Shai Carmi, Itsik Pe’er — 2015
• Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians.Yun Freudenberg‐Hua, Wentian Li, Avinash Abhyankar — 2016
• Incidence and epidemiology of non‐Hodgkin lymphoma and risk of second malignancy among 22 466 survivors in Israel with 30 years of follow‐upTamar Tadmor, Irena Liphshitz, Barbara Silverman — 2017

Related papers

• Evolutionary Dynamics of Plant Populations Studied by Population Genomics: Genomics of Adaptation: 適応をゲノムから探るTakashi Tsuchimatsu — 2018
• Population GenomicsOm P. Rajora — 2019
• Preparing the next generation of genomicists: a laboratory-style course in medical genomicsMichael D. Linderman, Ali Bashir, George A. Díaz — 2015
• Population Genomics of Filamentous Plant Pathogens-A Brief Overview of Research Questions, Approaches, and Pitfalls.Sydney E. Everhart, Nikita Gambhir, Remco Stam — 2020
• The Application of Population Genomics in Crop ResearchFan-Jing Yang, Wei Ma, Chuyu Ye — 2023
• Population Genomics of Fungal and Oomycete Pathogens.Niklaus J. Grünwald, Bruce A. McDonald, Michael G. Milgroom — 2016
• Harnessing population genomics to understand how bacterial pathogens emerge, adapt to crop hosts, and disseminate.Boris A. Vinatzer, Caroline Monteil, Christopher R. Clarke — 2014