Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells
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Summary
It is proposed that the quality of the IS predicts the effectiveness of CAR-modified immune cells, which provides a novel strategy to guide CAR therapy.
- Type
- article
- Published
- 2018-03-02
- Cited by
- 150
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W2785898023
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3661478
Keywords
Chimeric antigen receptor, Immunological synapse, Synapse, Cell biology, Antigen
References
- Micromanipulation of adhesion of a Jurkat cell to a planar bilayer membrane containing lymphocyte function-associated antigen 3 molecules
- Imaging of Cell-Cell Communication in a Vertical Orientation Reveals High-Resolution Structure of Immunological Synapse and Novel PD-1 Dynamics
- Three-dimensional segregation of supramolecular activation clusters in T cells
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- Cytotoxic immunological synapses
- 4-1BB Is Superior to CD28 Costimulation for Generating CD8+ Cytotoxic Lymphocytes for Adoptive Immunotherapy1
- Supported Planar Bilayers for Study of the Immunological Synapse
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- Design and Development of Therapies using Chimeric Antigen Receptor-Expressing T cells
- Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
- Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication.
- Measuring Cytotoxicity by Bioluminescence Imaging Outperforms the Standard Chromium-51 Release Assay
- A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells.
- T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells.
- Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
- Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.
- Bacteriology: A caring culture
- Considerations for the Clinical Application of Chimeric Antigen Receptor (CAR) T Cells: Observations from a Recombinant DNA Advisory Committee (RAC) Symposium June 15, 2010
Cited by
- Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology
- CD33/CD3-bispecific T-cell engaging (BiTE®) antibody construct targets monocytic AML myeloid-derived suppressor cells
- Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy
- Quality Control and Nonclinical Research on CAR-T Cell Products: General Principles and Key Issues
- Deep-learning based three-dimensional label-free tracking and analysis of immunological synapses of chimeric antigen receptor T cells
- Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells
- Natural killer cells as a promising therapeutic target for cancer immunotherapy
- Synthetic transcriptional synergy
- Bispecific T-Cell Redirection versus Chimeric Antigen Receptor (CAR)-T Cells as Approaches to Kill Cancer Cells
- Immunobiology of chimeric antigen receptor T cells and novel designs
- T cell receptor‐based cancer immunotherapy: Emerging efficacy and pathways of resistance
- P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation.
- Direct comparison of target-reactivity and cross-reactivity induced by CAR- and BiTE-redirected T cells for the development of antibody-based T-cell therapy
- Understanding the Spatial Topology of Artificial Immunological Synapses Assembled in T Cell-Redirecting Strategies: A Major Issue in Cancer Immunotherapy
- Engineering T cells for immunotherapy of primary human hepatocellular carcinoma
- Revving the CAR - Combination strategies to enhance CAR T cell effectiveness.
- Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells
- Chimeric antigen receptor signaling: Functional consequences and design implications
- CAR T cell entry into tumor islets is a two-step process dependent on IFNγ and ICAM-1
- Impact of ligand size and conjugation chemistry on the performance of universal chimeric antigen receptor T-cells for tumor killing.
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