Macrophage plasticity, polarization, and function in health and disease
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Summary
The protective and pathogenic role of the macrophage subsets in normal and pathological pregnancy, anti‐microbial defense, anti-tumor immunity, metabolic disease and obesity, asthma and allergy, atherosclerosis, fibrosis, wound healing, and autoimmunity are discussed.
- Type
- review
- Published
- 2018-09-01
- Cited by
- 4,387
- References
- 135
- OpenAlex
- https://openalex.org/W2782685575
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3621509
Keywords
Macrophage polarization, Macrophage, Disease, Function (biology), Plasticity
References
- Inducing Tolerance to Pregnancy
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- What are the roles of macrophages and monocytes in human pregnancy?
- Control of macrophage metabolism and activation by mTOR and Akt signaling
- Microglial M1/M2 polarization and metabolic states
- Macrophage plasticity and polarization in tissue repair and remodelling
- Alternatively activated microglia and macrophages in the central nervous system.
- Metabolic Reprograming in Macrophage Polarization
- Macrophage polarization in pathology
- Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells.
- Macrophage Polarization in Bacterial Infections
- Monocytes in atherosclerosis: subsets and functions
- Shaping of monocyte and macrophage function by adenosine receptors.
- Macrophage heterogeneity in liver injury and fibrosis.
- Orchestration of metabolism by macrophages.
- Microglial cell origin and phenotypes in health and disease
- Macrophage subsets in atherosclerosis
Cited by
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- Porphyromonas gingivalis inhibits M2 activation of macrophages by suppressing &agr;‐ketoglutarate production in mice
- Silencing LAIR‐1 in human THP‐1 macrophage increases foam cell formation by modulating PPAR&ggr; and M2 polarization
- MiR-202-5p Promotes M2 Polarization in Allergic Rhinitis by Targeting MATN2
- Transcriptome profile of rat genes in bone marrow-derived macrophages at different activation statuses by RNA-sequencing.
- CD3+ Macrophages Deliver Proinflammatory Cytokines by a CD3- and Transmembrane TNF-Dependent Pathway and Are Increased at the BCG-Infection Site
- Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model
- Effects of CB2 Receptor Modulation on Macrophage Polarization in Pediatric Celiac Disease
- Psoriasis and Leprosy: An Arcane Relationship
- A bite to fight: front-line innate immune defenses against malaria parasites
- Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis
- The Role of Macrophages in Neuroinflammatory and Neurodegenerative Pathways of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis: Pathogenetic Cellular Effectors and Potential Therapeutic Targets
- Spousal bereavement is associated with more pronounced ex vivo cytokine production and lower heart rate variability: Mechanisms underlying cardiovascular risk?
- Chlamydia pneumoniae-induced tumour necrosis factor alpha responses are lower in children with asthma compared with non-asthma
- Global analysis of alternative splicing in human cells of myeloid origin
- Biglycan is a new high-affinity ligand for CD14 in macrophages.
- Manipulating macrophage polarization and function using classical HDAC inhibitors: Implications for autoimmunity and inflammation.
- Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses
- Age-related M1/M2 phenotype changes in circulating monocytes from healthy/unhealthy individuals
- Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15II in Murine Model
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