Functional metagenomics reveals a novel carbapenem-hydrolyzing mobile beta-lactamase from Indian river sediments contaminated with antibiotic production waste.
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Summary
Insight is provided into a resistome shaped by an exceptionally strong and long-term antibiotic selection pressure and an improved knowledge of mobilized resistance factors in the external environment may make us better prepared for the resistance challenges that the authors may face in clinics in the future.
- Type
- article
- Published
- 2018-03-01
- Cited by
- 61
- References
- 66
- OpenAlex
- https://openalex.org/W2782420090
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4792447
Keywords
Metagenomics, Resistome, Biology, Integron, Antibiotic resistance
References
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- High abundances of class 1 integrase and sulfonamide resistance genes, and characterisation of class 1 integron gene cassettes in four urban wetlands in Nigeria
- Understanding antimicrobial discovery and resistance from a metagenomic and metatranscriptomic perspective: advances and applications
- Field-compatible protocol for detecting tetracyclines with bioluminescent bioreporters without pipetting steps.
- Identification and reconstruction of novel antibiotic resistance genes from metagenomes
- Industrial wastewater treatment plant enriches antibiotic resistance genes and alters the structure of microbial communities.
- Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes
- Clinical Resistome Screening of 1,110 Escherichia coli Isolates Efficiently Recovers Diagnostically Relevant Antibiotic Resistance Biomarkers and Potential Novel Resistance Mechanisms
- Whole Genome Sequencing of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Isolated From a Wastewater Treatment Plant in China
- New antibiotic resistance genes and their diversity
- Scandinavium goeteborgense gen. nov., sp. nov., a New Member of the Family Enterobacteriaceae Isolated From a Wound Infection, Carries a Novel Quinolone Resistance Gene Variant
- Geochemical and microbiological characterization of sediments at the mouth of Río de las Minas (Punta Arenas, Chile)
- The Peril and Promise of Integrons: Beyond Antibiotic Resistance.
- A Novel, Integron-Regulated, Class C β-Lactamase
- Combining metagenomics and metatranscriptomics to study human, animal and environmental resistomes
- Freshwater viral metagenome reveals novel and functional phage-borne antibiotic resistance genes
- Metagenomic study focusing on antibiotic resistance genes from the sediments of River Yamuna.
- Dissemination of antibiotic resistance genes (ARGs) via integrons in Escherichia coli: A risk to human health.
- The Association between Insertion Sequences and Antibiotic Resistance Genes
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