When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts
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Summary
This work considers how to optimise the handling of missing data during the planning stage of a randomised clinical trial and recommends analytical approaches which may prevent bias caused by unavoidable missing data.
- Type
- article
- Published
- 2017-12-06
- Cited by
- 2,317
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W2772803673
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11548982
Keywords
Missing data, Imputation (statistics), Computer science, Flowchart, Data mining
References
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- Reporting and analysis of trials using stratified randomisation in leading medical journals: review and reanalysis
- Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls
- Multiple Imputation in Practice
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- The thresholds for statistical and clinical significance – a five-step procedure for evaluation of intervention effects in randomised clinical trials
- Observer bias in randomised clinical trials with binary outcomes: systematic review of trials with both blinded and non-blinded outcome assessors
- Reanalyses of randomized clinical trial data.
- Randomized trials with missing outcome data: how to analyze and what to report
- Improper analysis of trials randomised using stratified blocks or minimisation
- Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis.
- Choosing sensitivity analyses for randomised trials: principles
- Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods
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- Guided Digital Cognitive Behavioral Program for Anxiety in Primary Care: Propensity-Matched Controlled Trial
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- Detailed statistical analysis plan for the Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction) randomised clinical trial on sildenafil versus placebo for pregnant women with severe early onset fetal growth restriction
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