Are Fusion Transcripts in Relapsed/Metastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?
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Summary
The associations between HNSCC patient's outcome following cetuximab treatment and lncRNA-containing fusions or the CD274-PDCD1LG2 fusion deserve validation in prospective clinical trials.
- Type
- article
- Published
- 2017-11-12
- Cited by
- 6
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2767473646
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33711705
Keywords
Medicine, Head and neck cancer, Oncology, Head and neck, Internal medicine
References
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- Emerging biomarkers in head and neck cancer in the era of genomics
- Functional Genomics Uncover the Biology behind the Responsiveness of Head and Neck Squamous Cell Cancer Patients to Cetuximab
- Prognostic factors and long‐term survivorship in patients with recurrent or metastatic carcinoma of the head and neck
- Clinical utility of a novel urine-based gene fusion TTTY15-USP9Y in predicting prostate biopsy outcome.
- Modeling Survival Data Extending The Cox Model
- Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck
- The role of re-irradiation of secondary and recurrent head and neck carcinomas. Is it a potentially curative treatment? A practical approach.
- The MLL recombinome of acute leukemias
- Surgical Salvage of Recurrent Cancer of the Head and Neck
- Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma.
- The landscape and therapeutic relevance of cancer-associated transcript fusions
- Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: analysis of data from the EXTREME and CRYSTAL studies.
- Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
- The MLL recombinome of acute leukemias in 2013
- Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study
- Platinum-based chemotherapy plus cetuximab in head and neck cancer.
- From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
- TopHat-Fusion: an algorithm for discovery of novel fusion transcripts
- DNA copy number variation and loss of heterozygosity in relation to recurrence of and survival from head and neck squamous cell carcinoma: a review
Cited by
- Prognostic and predictive factors in recurrent and/or metastatic head and neck squamous cell carcinoma: A review of the literature.
- Non-coding RNAs in cancers with chromosomal rearrangements: the signatures, causes, functions and implications
- Predictive Value of EGFR-PI3K-AKT-mTOR-Pathway Inhibitor Biomarkers for Head and Neck Squamous Cell Carcinoma: A Systematic Review
- Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer
- Recurrent UBE3C-LRP5 translocations in head and neck cancer with therapeutic implications
- A Transcriptomic Analysis of Laryngeal Dysplasia
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