Integrin activation by talin, kindlin and mechanical forces
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Summary
This Perspective discusses the current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity, and how integrin inactivators function in this framework.
- Type
- review
- Published
- 2019-01-01
- Cited by
- 459
- References
- 89
- Access
- Open access
- OpenAlex
- https://openalex.org/W2901606464
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:57373556
Keywords
Integrin, Cell biology, Extracellular matrix, Cell adhesion, Focal adhesion
References
- Integrins: bidirectional, allosteric signaling machines.
- Adhesion receptors of the immune system
- SHARPIN Regulates Uropod Detachment in Migrating Lymphocytes
- The cancer glycocalyx mechanically primes integrin-mediated growth and survival
- Dual-color superresolution imaging of genetically expressed probes within individual adhesion complexes
- Force sensing by mechanical extension of the Src family kinase substrate p130Cas.
- SHARPIN is an endogenous inhibitor of beta1-integrin activation
- Properties of the Force Exerted by Filopodia and Lamellipodia and the Involvement of Cytoskeletal Components
- Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands.
- Distinct chemokine signaling regulates integrin ligand specificity to dictate tissue-specific lymphocyte homing.
- Mechanically Activated Integrin Switch Controls α5β1 Function
- SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
- MAP4K4 regulates integrin-FERM binding to control endothelial cell motility
- Talins and kindlins; partners in integrin-mediated adhesion
- β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments
- Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)
- The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin
- The insider's guide to leukocyte integrin signalling and function
- The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain
- Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes
Cited by
- Integrin trafficking in cells and tissues
- α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes
- Elastic fibers and biomechanics of the aorta: Insights from mouse studies
- Mechano-regulation of proline metabolism and cancer progression by kindlin-2
- Tensile and compressive force regulation on cell mechanosensing
- Force-independent interactions of talin and vinculin govern integrin-mediated mechanotransduction
- Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment
- Kindlin Assists Talin to Promote Integrin Activation
- Lipid-DNA conjugates for cell membrane modification, analysis, and regulation
- Clathrin-containing adhesion complexes
- Chronic tissue damage: a common pathomechanism of genodermatoses
- Are Integrins Still Practicable Targets for Anti-Cancer Therapy?
- Discoidin domain receptor 1 interactions with myosin motors contribute to collagen remodeling and tissue fibrosis.
- Talin and Kindlin as Integrin‑Activating Proteins: Focus on the Heart
- Force Directed 'Mechanointeractome' of Talin-Integrin.
- Cell matrix adhesion in cell migration.
- How the mechanobiome drives cell behavior, viewed through the lens of control theory
- Slik phosphorylation of Talin T152 is crucial for proper Talin recruitment and maintenance of muscle attachment in Drosophila
- A kindlin-3–leupaxin–paxillin signaling pathway regulates podosome stability
- The Architecture of Talin1 Reveals an Autoinhibition Mechanism
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