Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
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Summary
Examination of the oral and gut microbiome of melanoma patients undergoing anti-programmed cell death 1 protein (PD-1) immunotherapy suggested enhanced systemic and antitumor immunity in responding patients with a favorable gut microbiome as well as in germ-free mice receiving fecal transplants from responding patients.
- Type
- article
- Published
- 2017-11-02
- Cited by
- 4,304
- References
- 79
- Access
- Open access
- OpenAlex
- https://openalex.org/W2766903152
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206659934
Keywords
Microbiome, Immunotherapy, Melanoma, Gut microbiome, Tumor immunology
References
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- Precision medicine using microbiota
- Anti-PD1 in the wonder-gut-land
- Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease
- Targeting the IDO1 pathway in cancer: from bench to bedside
- Microbiome: Focus on causation and mechanism
- Fecal microbiota transplantation: a promising strategy in preventing the progression of non-alcoholic steatohepatitis and improving the anti-cancer immune response
- Moving on from Metchnikoff: thinking about microbiome therapeutics in cancer
- Immunotherapy for non-small cell lung cancers: biomarkers for predicting responses and strategies to overcome resistance
- Exploring the Potential of Humoral Immune Response to Commensal Bifidobacterium as a Biomarker for Human Health, including Both Malignant and Non-Malignant Diseases: A Perspective on Detection Strategies and Future Directions
- Genomic Applications in Pathology
- Better lower bounds for missing species: improved non-parametric moment-based estimation for large experiments
- Gut microbes can shape responses to cancer immunotherapy
- Immunotherapy: Gut bacteria modulate responses to PD-1 blockade
- Gut microbiome: a new player in gastrointestinal disease
- PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
- Tumour microenvironment: Microbes matter
- Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
- The impact of the intestinal microbiota in therapeutic responses against cancer.
- Adjuvant Probiotics and the Intestinal Microbiome: Enhancing Vaccines and Immunotherapy Outcomes
- Current and developing immunotherapy in gastric adenocarcinoma
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