Importance of the C-Terminus of Aldehyde Dehydrogenase 7A1 for Oligomerization and Catalytic Activity
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Summary
Results suggest that the C-terminus of ALDH7A1 is crucial for the maintenance of both the oligomeric state and the catalytic activity of aldehyde dehydrogenase 7A1.
- Type
- article
- Published
- 2017-10-25
- Cited by
- 11
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W2766130549
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2833312
Keywords
Tetramer, Chemistry, Aldehyde dehydrogenase, NAD+ kinase, Mutant
References
- Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1
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- Determination of molecular weight
- Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.
- Determination of the regularization parameter in indirect-transform methods using perceptual criteria
- PRIMUS: a Windows PC-based system for small-angle scattering data analysis
- Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1.
- Morpheeins--a new structural paradigm for allosteric regulation.
- Environmental contaminants perturb fragile protein assemblies and inhibit normal protein function
- Global rigid body modeling of macromolecular complexes against small-angle scattering data.
- ALAD porphyria is a conformational disease.
- Synthesis of 1-piperideine-6-carboxylic acid produced by L-lysine-epsilon-aminotransferase from the Streptomyces clavuligerus gene expressed in Escherichia coli.
- Determination of the molecular weight of proteins in solution from a single small-angle X-ray scattering measurement on a relative scale
- Role and structural characterization of plant aldehyde dehydrogenases from family 2 and family 7.
- The crystal structure of seabream antiquitin reveals the structural basis of its substrate specificity
- Chemical synthesis of allysine ethylene acetal and conversion in situ into 1-piperideine-6-carboxylic acid: key intermediate of the alpha-aminoadipic acid for beta-lactam antibiotics biosynthesis.
- Mutations in antiquitin in individuals with pyridoxine-dependent seizures
- Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application
- Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source
- Aldehyde Dehydrogenase 7A1 (ALDH7A1) Is a Novel Enzyme Involved in Cellular Defense against Hyperosmotic Stress*
Cited by
- NAD+ Promotes Assembly of the Active Tetramer of Aldehyde Dehydrogenase 7A1
- Investigating the dynamic and complex oligomeric states of aldehyde dehydrogenase 7A1
- Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy
- RNA-Seq Study of Hepatic Response of Yellow-Feather Chickens to Acute Heat Stress
- Structure and mechanism of piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus.
- Impact of missense mutations in the ALDH7A1 gene on enzyme structure and catalytic function
- Structural and Biochemical Consequences of Pyridoxine-Dependent Epilepsy Mutations That Target the Aldehyde Binding Site of Aldehyde Dehydrogenase ALDH7A1
- Biochemical, Structural, and Computational Analyses of Two New Clinically Identified Missense Mutations of ALDH7A1
- Contribution of a C-Terminal Extension to the Substrate Affinity and Oligomeric Stability of Aldehyde Dehydrogenase from Thermus thermophilus HB27
- Structure of ALDH7A1 mutant W175A complexed with L-pipecolic acid
- Unraveling the molecular landscape and therapeutic strategies for acute kidney injury: insights from transcriptomics, network pharmacology, virtual screening, and in vitro experiments.
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