Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1
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Summary
The results suggest that the active site of ALDH7A1 is disassembled when the aldehyde site is vacant, and the C-terminus is a mobile element that forms quaternary structural interactions that aid aldealdehyde binding, relevant to the c.1512delG genetic deletion associated with pyridoxine-dependent epilepsy.
- Type
- article
- Published
- 2015-08-11
- Cited by
- 51
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W1172792186
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15406113
Keywords
Chemistry, Aldehyde dehydrogenase, Substrate (aquarium), Substrate specificity, Aldehyde
References
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- Structural Studies of Yeast Δ1-Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State
- The aldehyde dehydrogenase enzyme 7A1 is functionally involved in prostate cancer bone metastasis
Cited by
- Crystal Structure of Aldehyde Dehydrogenase 16 Reveals Trans-Hierarchical Structural Similarity and a New Dimer
- SAXS fingerprints of aldehyde dehydrogenase oligomers
- Genetic modifications associated with ketogenic diet treatment in the BTBRT+Tf/J mouse model of autism spectrum disorder
- Empirical power laws for the radii of gyration of protein oligomers.
- Structures of Proline Utilization A (PutA) Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function*
- Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD+ and retinoic acid
- Novel Homozygous Missense Mutation in ALDH7A1 Causes Neonatal Pyridoxine-Dependent Epilepsy
- Evidence for pipecolate oxidase in mediating protection against hydrogen peroxide stress
- Evidence of Mutational Heterogeneity of the ALDH7A1 Gene in Tunisian Families: Molecular and Insilico Investigations
- Current knowledge for pyridoxine-dependent epilepsy: a 2016 update
- Impact of Disease-Linked Mutations Targeting the Oligomerization Interfaces of Aldehyde Dehydrogenase 7A1
- The ALDH21 gene found in lower plants and some vascular plants codes for a NADP+‐dependent succinic semialdehyde dehydrogenase
- Structural Biology of Proline Catabolic Enzymes
- Importance of the C-Terminus of Aldehyde Dehydrogenase 7A1 for Oligomerization and Catalytic Activity
- Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline
- The Proline Cycle As a Potential Cancer Therapy Target
- Computer-Aided Modeling of Interaction between Aldehyde Dehydrogenase and Garcinia Biflavonoids
- Structural insights into betaine aldehyde dehydrogenase (BADH2) from Oryza sativa explored by modeling and simulations
- The quaternary structure of Thermus thermophilus aldehyde dehydrogenase is stabilized by an evolutionary distinct C-terminal arm extension
- NAD+ Promotes Assembly of the Active Tetramer of Aldehyde Dehydrogenase 7A1
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