Knockdown of GTPBP4 inhibits cell growth and survival in human hepatocellular carcinoma and its prognostic significance
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Summary
Findings suggest that GTPBP4 serves as an oncogene and plays a pivotal role in HCC development, which will be a potential therapeutic target or a biomarker for HCC.
- Type
- article
- Published
- 2017-10-05
- Cited by
- 18
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W2762740115
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19198624
Keywords
Gene knockdown, Cancer research, Oncogene, Cell growth, Carcinogenesis
References
- Up-regulation of GTPBP4 in colorectal carcinoma is responsible for tumor metastasis.
- The RNA expression signature of the HepG2 cell line as determined by the integrated analysis of miRNA and mRNA expression profiles.
- Mdm2 regulates HuR stability in human liver and colon cancer through Neddylation
- A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
- Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
- The EGFR signalling system in the liver: from hepatoprotection to hepatocarcinogenesis
- Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease
- Hepatocellular carcinoma: a global view
- The NOG1 GTP-binding Protein Is Required for Biogenesis of the 60 S Ribosomal Subunit*
- Association between murine double minute 2 T309G polymorphism and risk of liver cancer
- TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients
- Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up‐regulation of cytoplasmic p21 expression
- p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury
- A gene-expression signature as a predictor of survival in breast cancer.
- Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer.
- Altered expression of cell cycle and apoptotic proteins in human liver pathologies.
- MERAV: a tool for comparing gene expression across human tissues and cell types
- HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3
- OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs
Cited by
- Screening for implicated genes in colorectal cancer using whole-genome gene expression profiling
- Oncogene Delta/Notch-Like EGF-Related Receptor Promotes Cell Proliferation, Invasion, and Migration in Hepatocellular Carcinoma and Predicts a Poor Prognosis
- Knockdown of Ubiquitin Associated Protein 2-Like (UBAP2L) Inhibits Growth and Metastasis of Hepatocellular Carcinoma
- Feature screening in ultrahigh-dimensional varying-coefficient Cox model
- Recent advances in molecular biomarkers for patients with hepatocellular carcinoma
- Determining the Clinical Value and Critical Pathway of GTPBP4 in Lung Adenocarcinoma Using a Bioinformatics Strategy: A Study Based on Datasets from The Cancer Genome Atlas
- Integrated bioinformatic analysis of RNA binding proteins in hepatocellular carcinoma
- LncRNA FGD5-AS1 functions as an oncogene to upregulate GTPBP4 expression by sponging miR-873-5p in hepatocellular carcinoma
- Pan-cancer analysis revealed the significance of the GTPBP family in cancer
- Gene Expression Monotonicity across Bladder Cancer Stages Informs on the Molecular Pathogenesis and Identifies a Prognostic Eight-Gene Signature
- Integrated Analysis of Genomic and Transcriptomic Profiles Identified the Role of GTP Binding Protein-4 (GTPBP4) in Breast Cancer
- GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism
- GTPBP4: A New Therapeutic Target Gene Promotes Tumor Progression in Non-Small Cell Lung Cancer via EMT
- Single-cell transcriptome analysis reveals the metabolic changes and the prognostic value of malignant hepatocyte subpopulations and predict new therapeutic agents for hepatocellular carcinoma
- NOG1 downregulates type I interferon production by targeting phosphorylated interferon regulatory factor 3
- Significance of RNA Processing Factors in Prognosis and Treatment of Hepatocellular Carcinoma: Implications for Precision Medicine
- Foot-and-mouth disease virus VP1 degrades YTHDF2 through autophagy to regulate IRF3 activity for viral replication
- Distinct steps of nuclear maturation of human pre-60S complexes require the activity of GTPases including GNL3L
- Deep Functional Mapping For Predicting Cancer Outcome
- GTPBP4 enhances colorectal cancer cell proliferation by activating MYC-driven glycolysis
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