Pharmacological approach for drug repositioning against cardiorenal diseases.
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Summary
This review reports that angiotensin II type 1 receptor blockers show receptor-independent effects against reactive oxygen species generation in renal cells and nitrosonifedipine has an antioxidative effect and protects endothelial cells against oxidative stress, and pioglitazone has multiple effects that improve dysfunctions in vascular control regulated by adrenergic and calcitonin gene-related peptide-containing nerves.
- Type
- review
- Published
- 2017-01-01
- Cited by
- 8
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2760275775
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32450161
Keywords
Medicine, Drug, Cardiorenal syndrome, Pharmacology, Drug development
References
- Microalbuminuria Reduction With Valsartan in Patients With Type 2 Diabetes Mellitus: A Blood Pressure–Independent Effect
- Opportunities for Web-based Drug Repositioning: Searching for Potential Antihypertensive Agents with Hypotension Adverse Events
- Pioglitazone opposes neurogenic vascular dysfunction associated with chronic hyperinsulinaemia
- Drug repositioning and repurposing: terminology and definitions in literature.
- Effects of insulin on vascular responses to spinal cord stimulation and vasoactive agents in pithed rats
- Pioglitazone attenuates basal and postprandial insulin concentrations and blood pressure in the spontaneously hypertensive rat.
- Receptor-independent intracellular radical scavenging activity of an angiotensin II receptor blocker
- Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene−Related Peptide−Containing Nerve−Mediated Vasodilation in Pithed Rats
- Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation
- Anti-inflammatory and anti-oxidant properties of telmisartan in cultured human umbilical vein endothelial cells.
- Systems Pharmacology of Adverse Event Mitigation by Drug Combinations
- The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes.
- Antioxidant effects of photodegradation product of nifedipine.
- Reactive radical intermediates formed from illuminated nifedipine.
- Drug discovery for overcoming chronic kidney disease (CKD): development of drugs on endothelial cell protection for overcoming CKD.
- Insulin resistance-induced hypertension and a role of perivascular CGRPergic nerves.
- Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.
- Drug repositioning: identifying and developing new uses for existing drugs
- Hyperinsulinemia induces hypertension associated with neurogenic vascular dysfunction resulting from abnormal perivascular innervations in rat mesenteric resistance arteries
- Effect of illuminated nifedipine, a potent antioxidant, on intestinal and vascular smooth muscles
Cited by
- CDG Therapies: From Bench to Bedside
- Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database
- Intuitive repositioning of an anti-depressant drug in combination with tivozanib: precision medicine for breast cancer therapy
- Cascade Deep Forest With Heterogeneous Similarity Measures for Drug–Target Interaction Prediction
- Drug-Repositioning Approaches Based on Medical and Life Science Databases
- Drug discovery strategies for drug repositioning based on data science
- Preventive Effect of Betaine Against Cognitive Impairments in Amyloid β Peptide-Injected Mice Through Sirtuin1 in Hippocampus
- Current trends and future prospects of drug repositioning in gastrointestinal oncology
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