Drug repositioning: identifying and developing new uses for existing drugs
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Summary
Repositioning existing drugs for new indications could deliver the productivity increases that the industry needs while shifting the locus of production to biotechnology companies.
- Type
- review
- Published
- 2004-08-01
- Cited by
- 2,996
- References
- 51
- OpenAlex
- https://openalex.org/W2062941476
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205475073
Keywords
Biopharmaceutical, Drug repositioning, Business, Productivity, Drug discovery
References
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- Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.
- Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes
- Three-Way Street: Strategic Reciprocity in World Politics
- New ways to take old drugs.
- Colonizing therapeutic space: the overlooked science of drug husbandry
- Rebuilding Big Pharma ’ s Business Model
- Realism in drug discovery—could Cassandra be right?
Cited by
- A weighted and integrated drug-target interactome: drug repurposing for schizophrenia as a use case
- N-acetylcysteine prevents stress-induced anxiety behavior in zebrafish.
- Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation
- Opportunities for Web-based Drug Repositioning: Searching for Potential Antihypertensive Agents with Hypotension Adverse Events
- Konzepterkennung in Informationsnetzwerken
- Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRα from Drugbank database.
- A bibliometric review of drug repurposing
- Repurposing ebselen for decolonization of vancomycin-resistant enterococci (VRE)
- Drug Repurposing in Parkinson’s Disease
- Role of Overexpressed Transcription Factor FOXO1 in Fatal Cardiovascular Septal Defects in Patau Syndrome: Molecular and Therapeutic Strategies
- Multilayer architecture microfluidic network array for combinatorial drug testing on 3D-cultured cells
- Drug repositioning using disease associated biological processes and network analysis of drug targets.
- The role of Hsp20 in Alzheimer's disease
- Systems biology approaches and tools for analysis of interactomes and multi-target drugs.
- The Current State of Drug Discovery and a Potential Role for NMR Metabolomics
- Use and Development of Computational Tools in Drug Discovery: From Small Molecules to Cyclic Peptides
- NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS ARE ANTI-INFLAMMATORY AND TARGET DRY AGE-RELATED MACULAR DEGENERATION
- Diseño de fármacos asistido por computadora
- In vitro Tissue Engineering of Liver and Primary Lymphoid Tissues with Inverted Colloidal Crystal Scaffolds for Drug Testing Application.
- [Does cannabis use lead to schizophrenia?].
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