Model‐Based Interspecies Scaling of Glucose Homeostasis
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Summary
The integrated glucose insulin model, developed on clinical intravenous glucose tolerance test data, was scaled to describe data from similar tests performed in healthy rats, mice, dogs, pigs, and humans and was shown to accurately predict external preclinical IVGTT data.
- Type
- article
- Published
- 2017-09-28
- Cited by
- 19
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2758578252
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:310954
Keywords
Insulin, Pharmacodynamics, Glucose homeostasis, Homeostasis, Carbohydrate metabolism
References
- An Integrated Model for Glucose and Insulin Regulation in Healthy Volunteers and Type 2 Diabetic Patients Following Intravenous Glucose Provocations
- Optimization of the intravenous glucose tolerance test in T2DM patients using optimal experimental design
- Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet.
- An Integrated Glucose‐Insulin Model to Describe Oral Glucose Tolerance Test Data in Healthy Volunteers
- Physiological Parameter Values for Physiologically Based Pharmacokinetic Models
- Comparisons of Analysis Methods for Proof-of-Concept Trials
- Organ weights and blood flows of sheep and pig for physiological pharmacokinetic modelling.
- Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice
- An acute rat in vivo screening model to predict compounds that alter blood glucose and/or insulin regulation.
- Simultaneous measurement of insulin sensitivity, insulin secretion and the disposition index in conscious unhandled mice
- Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition
- The intravenous glucose tolerance test in cannulated Wistar rats: a robust method for the in vivo assessment of glucose-stimulated insulin secretion.
- Identification of the primary mechanism of action of an insulin secretagogue from meal test data in healthy volunteers based on an integrated glucose-insulin model
- Identification of the Mechanism of Action of a Glucokinase Activator From Oral Glucose Tolerance Test Data in Type 2 Diabetic Patients Based on an Integrated Glucose‐Insulin Model
- Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models
- Safe Induction of Diabetes by High-Dose Streptozotocin in Pigs
- Novel canine models of obese prediabetes and mild type 2 diabetes.
- Clinical significance of plasma mannose concentrations in healthy and diabetic dogs
- Glucagon suppression during OGTT worsens while suppression during IVGTT sustains alongside development of glucose intolerance in patients with chronic pancreatitis.
- What is the best size descriptor to use for pharmacokinetic studies in the obese?
Cited by
- Glucose, fructosamine, and insulin measurements in saliva of dogs: variations after an experimental glucose administration.
- Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
- A Model‐Informed Drug Discovery and Development Strategy for the Novel Glucose‐Responsive Insulin MK‐2640 Enabled Rapid Decision Making
- Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin
- An organ-based multi-level model for glucose homeostasis: organ distributions, timing, and impact of blood flow
- Mathematical Modeling for the Physiological and Clinical Investigation of Glucose Homeostasis and Diabetes
- A mechanism‐based pharmacokinetic model of remdesivir leveraging interspecies scaling to simulate COVID‐19 treatment in humans
- Hybrid modelling for stroke care: Review and suggestions of new approaches for risk assessment and simulation of scenarios
- A multi-scale in silico mouse model for insulin resistance and humanoid type 2 diabetes
- An Updated Organ-Based Multi-Level Model for Glucose Homeostasis: Organ Distributions, Timing, and Impact of Blood Flow
- Integrated experimental-computational analysis of a liver-islet microphysiological system for human-centric diabetes research
- A quantitative systems pharmacology approach to predict the safe‐equivalent dose of doxorubicin in patients with cardiovascular comorbidity
- Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research
- Interspecies and in vitro‐in vivo scaling for quantitative modeling of whole‐body drug pharmacokinetics in patients: Application to the anticancer drug oxaliplatin
- A multi-scale in silico mouse model for diet-induced insulin resistance
- Pharmacokinetic considerations for optimizing inhaled spray-dried pyrazinoic acid formulations
- Pharmacokinetic Considerations for Optimizing Inhaled Spray-Dried Pyrazinoic Acid Formulations
- Quantitative Approaches in Translational Cardiometabolic Research: An Overview
- Breaking Barriers Between Species: Integrated Multi‐Species PK Models Improve Human PK Predictions
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