Imaging the neuroimmune response to alcohol exposure in adolescent baboons: a TSPO PET study using 18F‐DPA‐714
Explore this paper's citation graph
Summary
Acute alcohol exposure increased the binding of 18F‐DPA‐714 to the brain in a non‐human primate model of alcohol exposure that reflects the ‘binge drinking’ situation in adolescent individuals, suggesting a ‘priming’ of glial cell function after initial alcohol exposure.
- Type
- article
- Published
- 2018-09-01
- Cited by
- 31
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2757773117
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25358656
Keywords
Alcohol, Ethanol, Translocator protein, Binge drinking, Alcohol dependence
References
- In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [11C]PK-11195 and animal PET following ethanol injury in rat striatum
- Current hypotheses on the mechanisms of alcoholism
- Standardized treatment of severe methanol poisoning with ethanol and hemodialysis.
- Ibudilast reduces alcohol drinking in multiple animal models of alcohol-dependence
- Alcohol and the human brain: a systematic review of different neuroimaging methods.
- Neuroimmune regulation of alcohol consumption: Behavioral validation of genes obtained from genomic studies
- Defining “Binge” Drinking as Five Drinks per Occasion or Drinking to a 0.08% BAC: Which is More Sensitive to Risk?
- Differential influence of propofol and isoflurane anesthesia in a non‐human primate on the brain kinetics and binding of [18F]DPA‐714, a positron emission tomography imaging marker of glial activation
- Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor.
- Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: the importance of microglia phenotype
- Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage
- [18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain
- Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats.
- Headspace gas chromatographic determination of ethanol: the use of factorial design to study effects of blood storage and headspace conditions on ethanol stability and acetaldehyde formation in whole blood and plasma.
- Adolescent binge alcohol exposure induces long-lasting partial activation of microglia
- Laboratory models of alcoholism: treatment target identification and insight into mechanisms
- Alcohol dependence: molecular and behavioral evidence
- Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults
- Why is Neuroimmunopharmacology crucial for the future of addiction research?
- Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment.
Cited by
- Animal models of binge drinking, current challenges to improve face validity.
- Dcf1 Deficiency Attenuates the Role of Activated Microglia During Neuroinflammation
- Impact of Acute Alcohol Exposure on P‐Glycoprotein Function at the Blood‐Brain Barrier Assessed Using 11C‐Metoclopramide PET Imaging
- Neuroimmune signaling in alcohol use disorder
- Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies
- Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review
- Its complicated: The relationship between alcohol and microglia in the search for novel pharmacotherapeutic targets for alcohol use disorders.
- Diagnostic and Therapeutic Potential of TSPO Studies Regarding Neurodegenerative Diseases, Psychiatric Disorders, Alcohol Use Disorders, Traumatic Brain Injury, and Stroke: An Update
- Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis
- Neuroimaging of inflammation in alcohol use disorder: a review
- Nalmefene alleviates the neuroimmune response to repeated binge‐like ethanol exposure: A TSPO PET imaging study in adolescent rats
- Contribution of TSPO imaging in the understanding of the state of gliosis in substance use disorders
- Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking
- The emerging tale of microglia in psychiatric disorders.
- Alcohol and the Brain
- Glia in Health and Disease
- Inflammatory Biomarkers in Addictive Disorders
- The neuroimmune system – where aging and excess alcohol intersect
- Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies
- Imaging the brain’s immune response to alcohol with [11C]PBR28 TSPO Positron Emission Tomography
Related papers
- 296. Correlating Peripheral and Central Markers of Neuroinflammation to PET Imaging of Translocator Protein (TSPO)
- 175. A Novel 18F-Labeled Pet Radioligand Accurately Quantifies Translocator Protein 18kDa (TSPO) in Monkey Brain
- The Translocator Protein
- Translocator Protein 18 kDa (TSPO) Expression in Multiple Sclerosis Patients
- The translocator protein (18 kDa) and its role in neuropsychiatric disorders
- Is there any correlation between binding and functional effects at the translocator protein (TSPO) (18 kDa)?
- Prevalence of Alcohol Dependence Among US Adult Drinkers, 2009–2011